Stem/progenitor-specific TF profiling identifies ligands of major pathways. Stem/progenitor-specific TF profiling identifies ligands of major pathways.

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Stem/progenitor-specific TF profiling identifies ligands of major pathways. Stem/progenitor-specific TF profiling identifies ligands of major pathways. (A) Overlap of genes showing ISC/EB expression (green), EC expression (red), Sox21 binding (blue), and cic binding (gray). See Dataset S4 for gene lists. (B) GO terms enriched in the 631 genes specifically expressed in ISC/EBs and with regulatory regions bound by both Sox21a and cic. (C) Major developmental signaling pathway ligands specifically expressed in ISC/EBs and bound by both Sox21a and cic. (D) Expression of Ilp6 in ISC/EBs. DAPI (blue), EGFP driven by Ilp6-GAL4 (green), and esg-lacZ (red). (Scale bars, 20 µm.) (E) Expression of egr in ISC/EBs. DAPI (blue), egr-GFP protein trap (green), and esg-lacZ (red). (Scale bars, 20 µm.)‏ David P. Doupé et al. PNAS 2018;115:48:12218-12223 ©2018 by National Academy of Sciences