1. Klotho depletion increases MHC class II expression in the CP
Klotho depletion increases MHC class II expression in the CP. (A–D) MHC II immunoreactivity in the CP of uninjected young (2 to 3 mo) vs. old (22 to 23 mo) WT mice (A–C) and of Cre-injected 19- to 22-mo-old WT vs.
Klotho depletion increases MHC class II expression in the CP. (A–D) MHC II immunoreactivity in the CP of uninjected young (2 to 3 mo) vs. old (22 to 23 mo) WT mice (A–C) and of Cre-injected 19- to 22-mo-old WT vs. Klothoflox/flox (Flox) mice measured 9 mo after i.c.v. injection (D and E). n = 5 to 7 mice per group. Coronal CP sections were double-labeled for MHC II (red) and for cytokeratin (gray) (A and D) or transthyretin (green) (B). [Scale bars: 100 µm (A and D), 30 µm (B).] *P < 0.05, ***P < by unpaired, two-tailed t test. Values in bar graphs are means ± SEM.
Lei Zhu et al. PNAS 2018;115:48:E11388-E11396
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