Expression of epidermal growth factor receptor in gastric carcinomas

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Expression of epidermal growth factor receptor in gastric carcinomas Takuo Takehana, Kazuyoshi Kunitomo, Shioto Suzuki, Koji Kono, Hideki Fujii, Yoshiro Matsumoto, Akishi Ooi Clinical Gastroenterology and Hepatology Volume 1, Issue 6, Pages 438-445 (November 2003) DOI: 10.1016/S1542-3565(03)00219-2

Figure 1 Mucosal gastric carcinoma immunostained for (A) EGFR and (B) p53. Immunostaining with 3+ intensity is seen in the well-differentiated tubular adenocarcinoma. A proportion of the p53-positive cells is also EGFR-positive. (Case 1; original amplification 10×.) Clinical Gastroenterology and Hepatology 2003 1, 438-445DOI: (10.1016/S1542-3565(03)00219-2)

Figure 2 Adenocarcinoma with different histologic subpopulations. EGFR staining is seen (A) in a papillary carcinoma but not (B) in a signet-ring cell carcinoma. The region within the black rectangle in (A) corresponds to the field in (C). FISH analysis of a serial section of (A) shows 3+ staining cancer cells have multiple scattered red signals of the EGFR gene (C). (Case 6; original amplification 20×.) Clinical Gastroenterology and Hepatology 2003 1, 438-445DOI: (10.1016/S1542-3565(03)00219-2)

Figure 3 Adenocarcinoma overexpressing EGFR. Three serial sections demonstrating (A) 3+ immunostaining of cancer tubules composed of (B) cells with marked cytological atypia (asterisks) that correspond to (C) cells with gene amplification. (Case 2; original amplification 10×.) Clinical Gastroenterology and Hepatology 2003 1, 438-445DOI: (10.1016/S1542-3565(03)00219-2)

Figure 4 Sections from FISH analyses showing clusters of amplified signals. (Case 5; original amplification 100×.) Clinical Gastroenterology and Hepatology 2003 1, 438-445DOI: (10.1016/S1542-3565(03)00219-2)

Figure 5 Sections from FISH analyses showing an absence of amplification in a tumor with 2+ immunostaining. (Case 7; original amplification 100×.) Clinical Gastroenterology and Hepatology 2003 1, 438-445DOI: (10.1016/S1542-3565(03)00219-2)