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Association of Epidermal Growth Factor Receptor Activating Mutations with Low ERCC1 Gene Expression in Non-small Cell Lung Cancer  David R. Gandara, MD,

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Presentation on theme: "Association of Epidermal Growth Factor Receptor Activating Mutations with Low ERCC1 Gene Expression in Non-small Cell Lung Cancer  David R. Gandara, MD,"— Presentation transcript:

1 Association of Epidermal Growth Factor Receptor Activating Mutations with Low ERCC1 Gene Expression in Non-small Cell Lung Cancer  David R. Gandara, MD, Peter Grimminger, MD, Philip C. Mack, PhD, Primo N. Lara, MD, Tianhong Li, MD, PhD, Peter V. Danenberg, PhD, Kathleen D. Danenberg, BSc  Journal of Thoracic Oncology  Volume 5, Issue 12, Pages (December 2010) DOI: /JTO.0b013e3181fd418d Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Distribution of excision repair cross-complementing 1 (ERCC1) mRNA expression levels by histology and epidermal growth factor receptor (EGFR) mutation status. ERCC1 mRNA expression levels, normalized to the endogenous standard ACTB, were plotted on the y axis in log 2. Patients were subdivided into four categories based on EGFR mutation status (wild-type [WT] versus mutant [MT]) and histology: adenocarcinoma (AC) versus squamous cell carcinoma (SCCA). In EGFR-WT tumors, ERCC1 levels were significantly higher in SCCA compared with AC (p < 0.001). Significant differences were also observed between AC with WT EGFR versus AC with mutant EGFR (p = 0.001), with ERCC1 levels lower in the EGFR-MT subpopulation. The small number of SCCA harboring EGFR mutations precluded statistical analysis. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181fd418d) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

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