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Virtual Histology in Everyday Gastrointestinal Endoscopy

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Presentation on theme: "Virtual Histology in Everyday Gastrointestinal Endoscopy"— Presentation transcript:

1 Virtual Histology in Everyday Gastrointestinal Endoscopy
Gursimran Kochhar, Michael B. Wallace  Clinical Gastroenterology and Hepatology  Volume 16, Issue 10, Pages (October 2018) DOI: /j.cgh Copyright © 2018 AGA Institute Terms and Conditions

2 Figure 1 NICE classification.
Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

3 Figure 2 (From Left to Right) (A) EGD with high definition showing abnormal mucosa. (B, C) EGD with NBI, showing a discrete area of nodular mucosa. (D, E) On near focus and NBI, mucosal pattern and vascular pattern appear regular. (F) EGD, with white light showing post-EMR resected site, with no residual polyp. EGD, esophagogastroduodenoscopy. Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

4 Figure 3 (From Left to Right) (A) Esophagogastroduodenoscopy with high definition and white light showing a nodular area along with an adjacent depressed area, (B, C) NBI confirming the nodular area and depressed malignant area. (D) Mucosal pattern and vascular pattern on NBI appear irregular. (E, F) Post-EMR, no residual abnormal mucosa seen. Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

5 Figure 4 (A) Transition of normal squamous esophageal mucosa (green asterisk) to dysplastic glandular epithelium (blue asterisk) that overlies an intramucosal adenocarcinoma that extends to the muscularis mucosa (black asterisk) (hematoxylin-eosin, original magnification ×10). (B) Higher power image of the transition from normal squamous esophageal mucosa (green asterisk) to dysplastic glandular epithelium (blue asterisk) that overlies an intramucosal adenocarcinoma. The glands in the intramucosal carcinoma range from single lumen (yellow asterisk) crowded multiple-lumen (orange asterisk) structures. The cells lining these neoplastic glands show a loss of apical mucin production, loss of polarity, a high degree of nuclear pleomorphism, and anisonucleosis. Mitotic figures are relatively easy to find (red asterisk) (hematoxylin-eosin, original magnification ×20). (C) Intramucosal adenocarcinoma (blue asterisk) extending to the muscularis mucosa (black asterisk). Underneath the muscularis mucosa is the vascular submucosa and deep margin, which are negative for tumor (black ink) (hematoxylin-eosin, original magnification ×10). Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

6 Figure 5 (From Left to Right) (A) High-definition white light showing a polypoid lesion with mucus cap. (B, C) NBI image showing darker lesion compared with the background, with brown vessels surrounding white structures. (D) A cloudy appearance with dark spots inside the crypts is noted, suggestive of sessile serrated polyp. (E) Shows lesion lifted for resection. (F) Post resection, no residual polyp tissue is seen. Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions


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