An ovine model of postinfarction dilated cardiomyopathy

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Presentation transcript:

An ovine model of postinfarction dilated cardiomyopathy Sina L Moainie, MD, Joseph H Gorman, MD, T.Sloane Guy, MD, Frank W Bowen, MD, Benjamin M Jackson, MD, Theodore Plappert, Navneet Narula, MD, Martin G St. John-Sutton, MBBS, Jagat Narula, MD, PhD, L.Henry Edmunds, MD, Robert C Gorman, MD The Annals of Thoracic Surgery Volume 74, Issue 3, Pages 753-760 (September 2002) DOI: 10.1016/S0003-4975(02)03827-4

Fig 1 (A) Serial transdiaphragmatic echocardiograms in short axis at the high papillary muscle level recorded from a representative animal at baseline, 30 minutes, 2, 5, and 8 weeks after infarction, illustrating progressive left ventricular dilation over time. (B) Serial transdiaphragmatic echocardiograms recorded in the left ventricular long axis view from a representative animal at baseline, 30 minutes, 2, 5, and 8 weeks after infarction demonstrating progressive left ventricular dilation over time. The Annals of Thoracic Surgery 2002 74, 753-760DOI: (10.1016/S0003-4975(02)03827-4)

Fig 2 Left ventricular end-systolic volume (mL) with error bars representing standard error. p ≤ 0.05, preinfarct versus 5 weeks; p ≤ 0.005 preinfarct versus 8 weeks. Line represents the left ventricular end-systolic volume. The Annals of Thoracic Surgery 2002 74, 753-760DOI: (10.1016/S0003-4975(02)03827-4)

Fig 3 Left ventricular sphericity index calculated as the ratio of left ventricular internal diameter (LVID) in short axis compared to left ventricular length (measured as distance from mitral annulus to apical endocardium in left ventricular long axis view). Error bars represent standard error. p ≤ 0.005 for 8 week data compared to preinfarct. Line represents the systolic (Sys) sphericity index. The Annals of Thoracic Surgery 2002 74, 753-760DOI: (10.1016/S0003-4975(02)03827-4)

Fig 4 Remote systolic wall thickening (mm) of remote myocardium measured as mean difference of wall thickness at end-diastole and at end-systole in two different regions remote from the infarct, the midseptum and posterior wall between the papillary muscles; error bars represent standard error. Line represents the wall thickening. The Annals of Thoracic Surgery 2002 74, 753-760DOI: (10.1016/S0003-4975(02)03827-4)

Fig 5 Regional perfusion of myocardial samples (mL/g/min) obtained from infarct, border zone, and remote myocardium as determined by serial microsphere injections. ■ = baseline; □ = perfusion at 2 weeks; = perfusion at 5 weeks; = perfusion at 8 weeks. Error bars represent standard error. p ≤ 0.005, infarct perfusion versus border zone and remote myocardial perfusion. The Annals of Thoracic Surgery 2002 74, 753-760DOI: (10.1016/S0003-4975(02)03827-4)

Fig 5 Regional perfusion of myocardial samples (mL/g/min) obtained from infarct, border zone, and remote myocardium as determined by serial microsphere injections. ■ = baseline; □ = perfusion at 2 weeks; = perfusion at 5 weeks; = perfusion at 8 weeks. Error bars represent standard error. p ≤ 0.005, infarct perfusion versus border zone and remote myocardial perfusion. The Annals of Thoracic Surgery 2002 74, 753-760DOI: (10.1016/S0003-4975(02)03827-4)

Fig 5 Regional perfusion of myocardial samples (mL/g/min) obtained from infarct, border zone, and remote myocardium as determined by serial microsphere injections. ■ = baseline; □ = perfusion at 2 weeks; = perfusion at 5 weeks; = perfusion at 8 weeks. Error bars represent standard error. p ≤ 0.005, infarct perfusion versus border zone and remote myocardial perfusion. The Annals of Thoracic Surgery 2002 74, 753-760DOI: (10.1016/S0003-4975(02)03827-4)

The Annals of Thoracic Surgery 2002 74, 753-760DOI: (10 The Annals of Thoracic Surgery 2002 74, 753-760DOI: (10.1016/S0003-4975(02)03827-4)

The Annals of Thoracic Surgery 2002 74, 753-760DOI: (10 The Annals of Thoracic Surgery 2002 74, 753-760DOI: (10.1016/S0003-4975(02)03827-4)

Fig 6 Sections of myocardium from border zone and remote myocardium stained with Masson’s trichrome. (A) Border zone low power (×2.5), arrow indicates the junction between infarct scar and border zone myocardium. (B) Border zone high power (×20), blue staining around myocytes indicates increased fibrosis. (C) Remote low power (×2.5). (D) Remote high power (×20), blue staining around myocytes indicates increased fibrosis. The Annals of Thoracic Surgery 2002 74, 753-760DOI: (10.1016/S0003-4975(02)03827-4)

Fig 7 Sections of myocardium from border zone (A) and remote (B) regions stained with Masson’s trichrome (magnification, ×20). The section from the border zone (A) shows extensive myocyte vacuolization (myofibrillarlytic cells). Myofibrillarlytic cells are not present in the remote region. The Annals of Thoracic Surgery 2002 74, 753-760DOI: (10.1016/S0003-4975(02)03827-4)