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Regional remodeling strain and its association with myocardial apoptosis after myocardial infarction in an ovine model  Godfred K. Yankey, MD, Tieluo.

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Presentation on theme: "Regional remodeling strain and its association with myocardial apoptosis after myocardial infarction in an ovine model  Godfred K. Yankey, MD, Tieluo."— Presentation transcript:

1 Regional remodeling strain and its association with myocardial apoptosis after myocardial infarction in an ovine model  Godfred K. Yankey, MD, Tieluo Li, MD, Ahmet Kilic, MD, Guangming Cheng, MD, PhD, Aditee Satpute, MD, Kinjal Savai, MSc, Shuying Li, BSc, Sina L. Moainie, MD, Deyanira Prastein, MD, Christopher DeFillipi, MD, Zhongjun J. Wu, PhD, Bartley P. Griffith, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 135, Issue 5, Pages e2 (May 2008) DOI: /j.jtcvs Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Summary of changes observed in left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV), and ejection fraction (EF) over time on echocardiogram. Increase in LVEDV and LVSV with decrease in EF show a global LV chamber dilatation and systolic dysfunction. All values are given as mean ± standard error of the mean. Symbols ∗, †, ‡, and Δ indicate P ≤ 0.05 as compared with preinfarct, postinfarct, 2 weeks, and 6 weeks, respectively. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 The infarct region shows a greater number of TUNEL-positive cells and the highest caspase-3 intensity. The adjacent region shows a lesser number of TUNEL-stained cells with a mild caspase-3 activity and remote region shows the fewest TUNEL-positive cells with minimal caspase-3 staining. Normal tissue is not shown but stained similar to the remote region of the LV myocardium. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 A, Representative Western blot. B, Relative abundance of protein expression: Poly (ADP-ribose) polymerase (PARP), caspase-3, and cytochrome c (Cyto c) normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and mitochondria Bax (Mito Bax) normalized to mitochondrial porin (VDAC). Symbols ∗ and † indicate P ≤ .05 as compared with tissue in the adjacent region and the infarction region of the LV myocardium, respectively. All values are given as mean ± SEM. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 Normalized cytochrome c, mitochondrial Bax, caspase-3 and poly (ADP-ribose) polymerse versus fractional contraction. For abbreviations, see Figure 3. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

6 Figure 5 Normalized cytochrome c, mitochondrial Bax, caspase-3, and poly (ADP-ribose) polymerase versus remodeling strain. For abbreviations, see Figure 3. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

7 Summary of changes observed in fractional contraction and in infarct, remote, and adjacent zones of LV myocardium at different study time points. The infarct region shows loss of contractile immediately after the MI becoming akinetic. Adjacent region shows a statistically significant loss of functional contraction by 2 weeks and becomes hypokinetic by 6 to 8 weeks. The remote region shows preserved contractile function by the end of the study. All values are given as mean ± SEM. Symbols ∗ and † indicate P ≤ .05 as compared with remote and adjacent regions, respectively. Symbols ‡ and Δ indicate P ≤ .05 as compared with preinfarct and 6 weeks, respectively. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

8 Summary of changes observed in remodeling strain in infarct, remote, and adjacent zones of LV myocardium at different study time points. The infarct displays the greatest remodeling strain. The difference in the degree of remodeling between the adjacent and the remote zones is statistically significant at both 6 weeks and time of termination. All values are given as mean ± SEM. Symbols ∗ and † indicate P ≤ .05 as compared with remote and adjacent regions, respectively. Symbols ‡, Δ, and # indicate P ≤ .05 as compared with postinfarct, 2 weeks, and 6 weeks, respectively. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

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