1. Myocardial functional recovery after fibroblast growth factor 2 gene therapy as assessed by echocardiography and magnetic resonance imaging 
Keith A Horvath, MD, John Doukas, PhD, Chia-Yang J Lu, MD, Noam Belkind, Rodney Greene, BS, Glenn F Pierce, PhD, MD, David A Fullerton, MD 
The Annals of Thoracic Surgery 
Volume 74, Issue 2, Pages (August 2002)
DOI: /S (02)

2. Fig 1
Region contractility as assessed by epicardial echocardiography of the ischemic myocardium for both groups. Six weeks after adenovirus vector-fibroblast growth factor 2 gene-activated matrix (AdFGF2 GAM) treatment there was a significant improvement in wall thickening versus baseline and versus untreated control animals (p < 0.05). (Tx = therapy.)
The Annals of Thoracic Surgery  , DOI: ( /S (02) )

3. Fig 2
Results of magnetic resonance imaging data demonstrate a significant improvement in contractility in the ischemic myocardium 6 weeks after adenovirus vector-fibroblast growth factor 2 gene-activated matrix (AdFGF2 GAM) treatment (p < 0.05). The nonischemic (normal) myocardium and the ischemic control (untreated) areas showed no significant improvement with time.
The Annals of Thoracic Surgery  , DOI: ( /S (02) )

4. Fig 3
Arteriogenesis as determined by vessel wall area with anti-α-actin immunohistochemical staining 6 weeks after randomization. There is a significant difference in arteriogenesis in the ischemic areas between the adenovirus vector-fibroblast growth factor 2 gene-activated matrix (AdFGF2 GAM) treated animals and the untreated control animals (p < 0.05). The arteriolar wall area after treatment was also significantly greater than that seen in the nonischemic (normal) myocardium for either group (p < 0.05).
The Annals of Thoracic Surgery  , DOI: ( /S (02) )

5. Fig 4
Vascular development in control and gene therapy-treated animals. Representative images taken from the ischemic zone of control (A and B) or matrix-formulated adenovirus vector-fibroblast growth factor 2-treated (C–F) animals. All images were taken at the same original magnification (×200); A, C, and E show trichrome-stained sections, and B, D, and F show the same area in a parallel section stained by anti-α-actin immunohistochemistry. C and D represent a different animal than E and F.
The Annals of Thoracic Surgery  , DOI: ( /S (02) )