ADVANCED Biomaterials

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Presentation transcript:

ADVANCED Biomaterials University Politehnica of Bucharest Faculty of Material Science and Engineering Biomaterials & Biointerfaces Group ADVANCED Biomaterials - And their importance to medical APPLICATIONS “BIONECA - Biomaterials and advanced physical techniques for regenerative cardiology and neurology” Central Library of University POLITEHNICA of Bucharest, Romania, October 2017

Faculty of Material Science and Engineering University Politehnica of Bucharest Faculty of Material Science and Engineering Biomaterials & Biointerfaces Group

Implants-tissue interfaces LAFIN Laboratory Some Experimental Results Implants-tissue interfaces

LAFIN Laboratory Some Experimental Results Scaffolds characterization SEM results on collagen scaffolds

New metallic biomaterials Biodegradable magnesium alloys Biodegradable iron based alloys porous tantalum Zr-2.5Nb Ti-Zr alloy NANOMATERIALS

MAGnesium alloys Pathophysiology/toxicology Element Magnesium Normal blood serum level 0.73–1.06 mmol/L Influences growth factor effectiveness Co-regulator of energy metabolism, cell proliferation, protein synthesis, onset of DNA synthesis Regulator of more than 350 proteins Stabilizer of DNA and RNA Long-term influence on cellular reactions Calcium Normal serum level 0.919–0.993 mg/L Most abundant mineral in the human body (1–1.1 kg) Mainly stored in bone, teeth Is tightly regulated by homeostasis of skeletal, renal and intestinal mechanism Zinc Normal blood serum level 12.4–17.4 lmol/L Trace element Essential for the immune system Co-factor for specific enzymes in bone and cartilage [98,99] Neurotoxic at higher concentrations Zirconium exhibits good biocompatibility and osseointegration both in vitro and in vivo (surpassing even titanium) Divalent Cation Metabolism: Magnesium, James T. McCarthy, Rajiv Kumar

Immersion tests of experimental magnesium alloys 7 days 14 days 30 days A B C PBS (A) HBSS (B) DMEM +10%FBS (C) Surface macro-morphologies of MgCa0.8 after 7 , 14 and 30 days in:

Conclusions New metallic biomaterials Surface modifications of the metallic biomaterials New processing technologies for metals Scaffolds vs. implants Interactions cells / drugs / biomaterials

Acknowledgement