Peptides Signal Mitochondrial Stress

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Peptides Signal Mitochondrial Stress Janine Kirstein-Miles, Richard I. Morimoto  Cell Metabolism  Volume 11, Issue 3, Pages 177-178 (March 2010) DOI: 10.1016/j.cmet.2010.02.011 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Mitochondrial Unfolded Stress Response (UPRmt) Is Signaled by Peptides Mitochondrial stress activates the proteolytic activity of ClpXP either by degradation of misfolded proteins into peptides (scenario I) or releasing a ligand (scenario II). The export of either the peptides or the ligand by the ABC transporter HAF-1 transmits the UPRmt signal to the cytosol. It is proposed that either the recognition of the peptides or the ligand by specific receptors or the efflux rate (scenario III) is the signal to activate the transcription factors bZIP and UBL5/DVE1. Upon redistribution from the cytosol into the nucleus, the transcription factors activate the expression of mitochondrial chaperones, which subsequently translocate to the mitochondria to rebalance the mitochondrial proteostasis. Cell Metabolism 2010 11, 177-178DOI: (10.1016/j.cmet.2010.02.011) Copyright © 2010 Elsevier Inc. Terms and Conditions