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F.-Nora Vögtle, Chris Meisinger  Developmental Cell 

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Presentation on theme: "F.-Nora Vögtle, Chris Meisinger  Developmental Cell "— Presentation transcript:

1 Sensing Mitochondrial Homeostasis: the Protein Import Machinery Takes Control 
F.-Nora Vögtle, Chris Meisinger  Developmental Cell  Volume 23, Issue 2, Pages (August 2012) DOI: /j.devcel Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Sensing Mitochondrial (Dys)function at the Protein Import Machinery (A) In healthy mitochondria, ATFS-1 is imported via the presequence pathway after rapid degradation by the matrix protease Lon. Δψ, membrane potential; MPP, mitochondrial presequence peptidase. (B) In stressed mitochondria, ATFS-1 import is inhibited, thereby favoring nuclear translocation where it activates transcription of stress response genes. P, phosphorylation. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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