1. The Regulatory T Cell Transcriptosome: E Pluribus Unum
Talal Chatila 
Immunity 
Volume 27, Issue 5, Pages (November 2007)
DOI: /j.immuni
Copyright © 2007 Elsevier Inc. Terms and Conditions

2. Figure 1 Positive Reinforcement of Foxp3 and TGF-β-Dependent Circuits
TGF-β signaling at its heterodimeric receptor (TGF-βRI–TGF-βRII) results in the phosphorylation of the TGF-β-regulated transcriptional activators Smad2 and Smad3 proteins, their association with Smad4, and translocation to the nucleus. Smad-dependent induction of Foxp3 in turn reinforces TGF-β-dependent gene expression, including the transcription of TGF-βRI. A proposed mechanism involves the promotion by Foxp3 of Smad protein retention in the nucleus.
Immunity  , DOI: ( /j.immuni )
Copyright © 2007 Elsevier Inc. Terms and Conditions