The Avian Influenza Virus Polymerase Brings ANP32A Home to Roost

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The Avian Influenza Virus Polymerase Brings ANP32A Home to Roost Andrew Mehle Cell Host & Microbe Volume 19, Issue 2, Pages 137-138 (February 2016) DOI: 10.1016/j.chom.2016.01.013 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 ANP32A Controls the Host Range of the Influenza Virus Polymerase Avian influenza virus polymerases function efficiently in avian cells (left) but are highly attenuated in mammalian cells and do not form competent replication complexes (right). Long et. al screened radiation hybrid cells to identify chicken ANP32A as a missing co-factor that restores activity of avian viral polymerases in a mammalian host and is thus a major determinant of influenza virus host range. Cell Host & Microbe 2016 19, 137-138DOI: (10.1016/j.chom.2016.01.013) Copyright © 2016 Elsevier Inc. Terms and Conditions