1. Warfare between Host Immunity and Bacterial Weapons
Manda Yu, Erh-Min Lai 
Cell Host & Microbe 
Volume 21, Issue 1, Pages 3-4 (January 2017)
DOI: /j.chom
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
E. tarda Uses Its T6SS to Suppress Inflammasome Activation Elicited by a T3SS
The T3SS of E. tarda injects effectors that have been shown to be important for intracellular replication and cytotoxicity of macrophages (Zhang et al., 2016), although the working mechanisms of these effectors are not well characterized. Chen et al. (2017) demonstrate that the T3SS apparatus induces the activation of inflammasomes, the key regulators of pyroptosis. In order to suppress pyroptosis, the T6SS of E. tarda secretes the effector EvpP to inhibit the oligomerization of ASC. The suppression of inflammasome activation and pyroptosis is suggested to be beneficial to bacterial colonization in the host.
Cell Host & Microbe  , 3-4DOI: ( /j.chom )
Copyright © 2017 Elsevier Inc. Terms and Conditions