1. Innate DNA Sensing Moves to the Nucleus
Leonie Unterholzner, Andrew G. Bowie 
Cell Host & Microbe 
Volume 9, Issue 5, Pages (May 2011)
DOI: /j.chom
Copyright © 2011 Elsevier Inc. Terms and Conditions

2. Figure 1
Dual Function of IFI16 in Endothelial Cells Infected with Kaposi Sarcoma-Associated Herpesvirus
IFI16 can sense viral DNA and activate transcription factors such as NF-κB via the adaptor protein STING. This leads to the transcription of proinflammatory cytokines such as pro-interleukin-1β (pro-IL-1β). Kerur et al. demonstrate that after the sensing of KSHV DNA in the nucleus, IFI16 can also associate with the inflammasome component ASC. This leads to the translocation of the IFI16-ASC complex to the cytosol and the activation of caspase-1 (Casp-1), which processes pro-IL-1β to its active form IL-1β.
Cell Host & Microbe 2011 9, DOI: ( /j.chom )
Copyright © 2011 Elsevier Inc. Terms and Conditions