Altered cell migration factors and increased intestinal tumorigenesis in APC1638N/+ mice. Altered cell migration factors and increased intestinal tumorigenesis.

Slides:

Advertisements

Similar presentations

Glioma-derived soluble factor(s) enhance IL-10 signaling.

Advertisements

Chronic stress accelerated DSS-induced colitis.

Expression of α5β1-integrin enhances EboV GP-mediated infection of GD25 cells. Expression of α5β1-integrin enhances EboV GP-mediated infection of GD25.

Dysregulation of Wnt/β-catenin and EphB/EphrinB signaling after 56Fe radiation. Dysregulation of Wnt/β-catenin and EphB/EphrinB signaling after 56Fe radiation.

Ongoing DNA damage, induction of cellular senescence, and acquisition of the senescence-associated secretory phenotype 12 mo after 56Fe radiation. Ongoing.

Decreased cell polarity and adhesion protein expression after 56Fe radiation. Decreased cell polarity and adhesion protein expression after 56Fe radiation.

Pretreatment of VSV-GPΔ to form VSV-GP19K rescues infection in the α5β1-integrin-negative CHO cells. Pretreatment of VSV-GPΔ to form VSV-GP19K rescues.

Integrin-Linked Kinase Is Indispensable for Keratinocyte Differentiation and Epidermal Barrier Function Samar Sayedyahossein, Alena Rudkouskaya, Valerie.

Long-term decrease of IEC migration after 56Fe radiation relative to γ-rays. Long-term decrease of IEC migration after 56Fe radiation relative to γ-rays.

Klotho reduction increases the expression of cytokine response factors in the CP. (A–C) ICAM1 (A and B) and IRF7 (C) immunoreactivity in the CP of 19-

Impaired lymphatic valve protrusion in Tie2Cre;Piezo1cKO mice.

Heavy-ion radiation decreases expression of key cellular tight junction proteins and alters microtubule dynamics in mouse intestine. Heavy-ion radiation.

Long-term up-regulation of proliferative markers and down-regulation of cell migration factors along with increased intestinal metaplasia after 56Fe radiation.

Klotho depletion increases MHC class II expression in the CP

Klotho reduction causes macrophage invasion into the CP

25(OH)D and 1,25(OH)2D perfusion treatment effect on cancer-related markers: IF stains illustrating expression levels for Ki-67 (A), cyclin D1 (B), ErbB-2.

Cells from TUM622 acini are capable of self-renewal and recapitulate the intratumoral heterogeneity observed in the PDX model and original human tumor.

CAFs enhance the acinar forming capacity of SOX2oe TUM622 cells and suppress dysplasia. CAFs enhance the acinar forming capacity of SOX2oe TUM622 cells.

TUM622 is capable of forming acinar-like structures in 3D ECM

Sunitinib plus rMVA–CEA–TRICOM vaccine decreased tumor burden and increased intratumoral infiltration of T lymphocytes in the MC38-CEA colon carcinoma.

Expression of IL-1α in goblet cells and their destruction during DSS-induced colitis. Expression of IL-1α in goblet cells and their destruction during.

Radiation resistance and stem-like cells in brain tumors

Volume 22, Issue 5, Pages (November 2012)

Smaller T cell zone FRC areas in aged spleens.

Macrophage-specific ablation of Vegfa in PyMT implant tumors blocks blood vessel permeability and tumor cell intravasation at the TMEM. A and C, immunofluorescence.

Microarray analysis of phospho-Twist1–responsive genes.

Tregs and APC subsets in TDLNs of patients with cervical cancer.

Detection and tracking of individual SNAP-tagged proteins on the surface of living cells. Detection and tracking of individual SNAP-tagged proteins on.

Lysozyme expression in isolated Paneth cells and linage tracing of Notch1+ cells Lysozyme expression in isolated Paneth cells and linage tracing of Notch1+

PD-1 expression on HCC-infiltrating B cells and its clinical significance. PD-1 expression on HCC-infiltrating B cells and its clinical significance. A–H,

Fig. 5 Local gel scaffold for T cell memory response.

CD169+ macrophages mediate Lm translocation to the splenic T cell zones. CD169+ macrophages mediate Lm translocation to the splenic T cell zones. (A) Confocal.

TrkB-T1 is upregulated in cerebellum of Pex14ΔC/ΔC BL/ICR mouse at P3.

BDNF expression in the cerebellum and brain stem region.

Inhibition of VEGFA or macrophage-specific ablation of Vegfa from TIE2hi/VEGFAhi TMEM macrophages reduces vascular permeability and tumor cell intravasation.

Effect of antiangiogenic TKIs and rMVA–CEA–TRICOM vaccine on tumor compactness, tight junctions, and intratumoral pressure in the MC38-CEA model. Effect.

Therapeutic administration of Areg myogenesis during infection.

Obesity aggravates tumor desmoplasia.

Existence of a nuclear NFATc1–STAT3 complex in pancreatic cancer.

ILK knockdown decreases mTOR signaling in PKD kidneys.

Integrative analysis incorporating histopathology, transcript-based assessment of AR signaling and NEPC score, TP53 and RB1 genomic status, and clinical.

Silencing Ifngr1 in the CMT167 line confers decreased response to IFNγ in vitro and in vivo. Silencing Ifngr1 in the CMT167 line confers decreased response.

Imaging intracellular endosymbiont E. coli by fluorescent microscopy.

Cell migration defects in Nap1khlo explants and embryos.

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

Fig. 1. Loss of PC following INT depletion

Islet mass and β-cell proliferation is decreased in Hhip–/– embryos (Hip1 in figure). Islet mass and β-cell proliferation is decreased in Hhip–/– embryos.

Robo3 in the GnRH neuronal system.

High-affinity binding to the hypervariable region of the β1 I-like domain controls signaling to fibronectin fibrillogenesis. High-affinity binding to the.

Defects in neuronal cell migration from the SVZ

Fig. 6. Mucus analysis of lungs from allergic and tolerized mice

Fig. 1. Loss of PC following INT depletion

PMPs survive STZ cytotoxicity and produce larger colonies with a higher yield of insulin+ progeny. PMPs survive STZ cytotoxicity and produce larger colonies.

IGF1R is present in endometrial luminal epithelium at the receptive phase. IGF1R is present in endometrial luminal epithelium at the receptive phase. Endometrial.

Metformin and rapamycin decreased tumor weights in obese prediabetic mice. Metformin and rapamycin decreased tumor weights in obese prediabetic mice. A:

CPI-444 efficacy requires CD8+ T cells and is associated with increased CD73 expression. CPI-444 efficacy requires CD8+ T cells and is associated with.

Diaphanous is required presynaptically for normal synaptic growth.

Fig. 1. DEL-1 is expressed by human and mouse osteoclasts.

Autophagy restrains pancreatic inflammation and expression of pTBK1, CCL5, and PD-L1 in vivo. Autophagy restrains pancreatic inflammation and expression.

Volume 139, Issue 3, Pages (September 2010)

EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo. EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo.

CLIC1 is upregulated in invadopodia of fibrin-embedded tumor and endothelial cells. CLIC1 is upregulated in invadopodia of fibrin-embedded tumor and endothelial.

Quantification of TUNEL staining and OS length among the rab11a constructs. Quantification of TUNEL staining and OS length among the rab11a constructs.

Activation status of CD8+ T cells.

PC loss in Nhe6-null mouse cerebellum, female and male.

Leukocyte populations in normal and neoplastic breast tissues.

CD36 expression is coordinately regulated in multiple cellular compartments. CD36 expression is coordinately regulated in multiple cellular compartments.

CD36 expression in tissue adjacent and distal to the tumor.

Complete intestinal metaplasia (IM) is characterised by goblet cells stained red or blue by alcian blue (pH 2.5)-periodic acid Schiff stain and by the.

AXL knockout does not prevent dormancy.

Presentation transcript:

Altered cell migration factors and increased intestinal tumorigenesis in APC1638N/+ mice. Altered cell migration factors and increased intestinal tumorigenesis in APC1638N/+ mice. (A) Increased intestinal tumor frequency is presented graphically showing higher tumorigenesis after 56Fe relative to sham and γ-radiation. (B) Immunoblot images showing increased EphB3 and β1-integrin expression and decreased Claudin1, Zo-1, and Map1b expression in tumor and adjacent normal tissues from APC1638N/+ mice. (C) Representative images of Par3 showing decreased expression in normal and tumor tissues after 56Fe radiation. (Scale bars, 10 μm.) (D) Immunofluorescence images showing decreased expression of E-cadherin in normal and tumor tissues after 56Fe radiation. (Scale bars, 10 μm.) (E) Representative images showing increased expression of Cyclin D1 in both normal and tumor tissues after 56Fe radiation. (Scale bars, 10 μm.) (F and G) Intestinal sections were stained using Alcian blue to score for mucin-producing goblet cells, a differentiated cell type in intestine, in normal and tumor tissues, and results are presented graphically showing decreased number after 56Fe radiation; *, significant relative to control; **, significant relative to γ-rays. Statistical significance is set at P < 0.05 and error bars represent mean ± SEM. Santosh Kumar et al. PNAS 2018;115:42:E9832-E9841 ©2018 by National Academy of Sciences