Heart Pump and Circulatory System

Agenda Review of Team Action Items Laboratory Layout and Cleanup System Response Observations LabVIEW Development Machining Plans Electrical System Updated BOM Test Plans Risk Assessment Plans for MSD II

Review of Team Action Items Group: Generate detailed test plans Update BOM Develop detailed plans for MSD 2 Develop list and answer questions for team progress report Update Risk Assessment Kevan: Ensure plate is received (and check quality, etc) Create machining plan and timeline for parts Machine parts Assist ventricle fabrication and testing Susan: Edit Edge from review comments Work with Mike during team meeting to develop LabVIEW program and test sensors for accuracy Force and material analysis for the Ventricle Write up team progress report Mike: Develop test protocols for sensors and test using labview Work with Blake to develop new compliance tank design as backup Finish simulink analysis Work with Susan to begin layout of control system Blake: Finalize simulink modeling; look over with Dr. Rice Find flow outputs along loop using flow meter and pressure sensors Verify sealing components throughout model (ex. O-rings, Compliance tank caps) Additional analysis to compliance tanks Henry: Fabricate the ventricle Test the ventricle Assist in machining of new parts Assist in the implementation of the driver to our ventricle pump

Progress Report

Proposed Pressure Sensor Location

Proposed Laboratory Layout

Laboratory Maintenance Weekly Procedure: (Post-Experimentation) Drain distilled water from system Siphon out water by priming hose from aortic compliance tank to nalgene container Force out systems water via vacuum pressure Semi-Annual Procedure: Add 10 grams of Alconox to 1 liter of distilled water & mix Pour solution into aortic tank of system Initiate system for operation Run system for approximately 10 minutes until tubing cloudiness becomes clear Drain solution Disassemble ventricle pump, valves, tanks, sensors Rinse interior of all components Store components in lab storage room

System Response Observations Motivation: Analyze the total latency of air driver. Methods: Use Oscilloscope to measure delay from Computer Signal to Solenoid trigger. Compare various speeds(1Hz, 1.5Hz, 2Hz, 2.5Hz) Analysis: Results found no statistically relevant variability in latency at various speeds with an average of ~59ms. Conclusion: Latency will be evaluated for relevance during system testing and used to tune code.

Calibration Flowchart

LabVIEW Programs (Flowmeter)

LabVIEW Programs (Relay)

Prototyping Progress The mold turned out very well. The air bubbles were minimal and largely restricted to the flange; where it will least affect the structural integrity of the ventricle. These air bubbles could have been avoided, but I poured the mix a little too fast and may have been clamped down a bit quick. Some of the surfaces are a bit uneven as well. This can be solved with some extra sanding of some of the harder to reach places. The ventricle compresses much easier than expected, while still appearing to be very durable. Overall, these are very successful results

Future Prototyping Goal: Create several ventricle prototypes that can simulate physiological conditions based on wall thickness and compare to theoretical values predicted using finite element analysis. Plan: Mold additional ventricle prototypes with Dragon Skin silicone (of varying thicknesses) and compare to current prototype performance. Outcome: Ventricle chosen best models desired physiological conditions of a human heart.

Machining Plans The drawings have been refined to their current state as shown here. We consulted with SME Rob Kranick who had some ideas, especially for sealing the chamber. However this was before the revelation that the ventricle will require considerably less pressure to compress. We can combine this with how smoothly the rough assembly went to make the call that we will not need the design change we had originally intended for dealing with the seal

Current Status -12’’x12’’x1/2’’ cut down to size -Currently 5.7’’x5.7’’x1/2’’ plates

Future Machining In order to maintain a proper seal in the chamber, the slots for the acrylic tubes need to be as concentric as possible - all other drilled holes are based on their dimension. The next phase of the process will be to machine the tube slots and ensure a proper fit before drilling the through holes used to secure the chamber in place to ensure accuracy. The ventricle hole, however, will need to be re-drawn in order for the machine shop to accurately advise us on how to machine it (radius of arc instead of ellipse).

Electrical Schematic DAQ Regulator amp Relays New Additions Circled

Air Driver Prototype Reduced risk with emergency stop button and circuit breaker Internal solenoid for noise reduction Currently using box donated by the construct

Updated BOM

Test Plans Solenoid Testing (S1) Compliance Testing (S2, S3, and S4) Ventricle Pressure Testing (S5, S6, and S20) Life Cycle Testing (S7) Maintenance Testing (S8) Flowmeter Testing (S9) Equilibrium Testing (S11 and S15) Air Safety Testing (S14) Electronic Safety Testing (S16) Pressure Input Regulation Testing (S17) Ease of Use Testing (S10, S12, S13, and S18) Cost Testing (S21)

Flowmeter Testing

Pressure Input Regulation Testing

Lab Cleanup Testing Plans Bacterial film (biofilm) buildup testing Leave a small amount of moisture remaining in the system Allow for system to sit without running for multiple days/weeks Record Observations per day Room Temperature Amount of moisture in the system Odors from within the system Visual cloudiness on inner walls of tubing and tanks Swab cloudy region of inner walls of tubing Culture bacterial film Determine additive to avoid or eliminate biofilm during storage

Updated Risk Assessment

Plans for MSD 2

Plans for MSD 2 Continued

Plans for MSD 2 Continued

QUESTIONS?