Figure 4 Simplified T cell and antigen presenting

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Figure 4 Simplified T cell and antigen presenting cell pathways involving rheumatoid arthritis-risk loci gene products Figure 4 | Simplified T cell and antigen presenting cell pathways involving rheumatoid arthritis-risk loci gene products. Thirty-five rheumatoid arthritis (RA)-risk loci gene products (red) are mapped to simplified signalling pathways in T cells and antigen presenting cells (APCs). Here, we show the gene products known to be part of signalling pathways in T cells and APCs, and the interactions between these pathways. Ag, antigen; AKT, RAC-α serine/threonine-protein kinase; AP-1,transcription factor AP-1; BCR, B-cell receptor; CD40L, CD40 ligand; CSF2RB, cytokine receptor common subunit β; ERBB2, receptor tyrosine-protein kinase erbB2; FYN, tyrosine-protein kinase Fyn; ICOS, inducible T-cell costimulator; IL-1R, interleukin-1 receptor; IL-3RA, interleukin-3 receptor subunit α; LYN, tyrosine-protein kinase Lyn; NFAT, nuclear factor of activated T-cells; NF-κB, nuclear factor κB; PI3K, phosphatidylinositol 3-kinase; TCR, T-cell receptor; TLR, Toll-like receptor; TNFR, TNF receptor. Kim, K. et al. (2016) Update on the genetic architecture of rheumatoid arthritis Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.176