Genetic Landscape of Eurasia and “Admixture” in Uyghurs

Slides:



Advertisements
Similar presentations
Length Distributions of Identity by Descent Reveal Fine-Scale Demographic History Pier Francesco Palamara, Todd Lencz, Ariel Darvasi, Itsik Pe’er The American.
Advertisements

TFIIH Subunit Alterations Causing Xeroderma Pigmentosum and Trichothiodystrophy Specifically Disturb Several Steps during Transcription Amita Singh, Emanuel.
Previous Estimates of Mitochondrial DNA Mutation Level Variance Did Not Account for Sampling Error: Comparing the mtDNA Genetic Bottleneck in Mice and.
Connexin Mutations in Skin Disease and Hearing Loss David P. Kelsell, Wei-Li Di, Mark J. Houseman The American Journal of Human Genetics Volume 68, Issue.
Differential Relationship of DNA Replication Timing to Different Forms of Human Mutation and Variation Amnon Koren, Paz Polak, James Nemesh, Jacob J. Michaelson,
Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.
Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages (January.
Alternative Splicing QTLs in European and African Populations Halit Ongen, Emmanouil T. Dermitzakis The American Journal of Human Genetics Volume 97, Issue.
A Multilocus Model of the Genetic Architecture of Autoimmune Thyroid Disorder, with Clinical Implications Veronica J. Vieland, Yungui Huang, Christopher.
A Hydrodynamic Model for Hindered Diffusion of Proteins and Micelles in Hydrogels Ronald J. Phillips Biophysical Journal Volume 79, Issue 6, Pages
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part I: Methods and Power Analysis Douglas F. Levinson, Matthew D. Levinson, Ricardo Segurado,
Genomewide Comparison of DNA Sequences between Humans and Chimpanzees Ingo Ebersberger, Dirk Metzler, Carsten Schwarz, Svante Pääbo The American Journal.
Fragile X and X-Linked Intellectual Disability: Four Decades of Discovery Herbert A. Lubs, Roger E. Stevenson, Charles E. Schwartz The American Journal.
Abraham's Children in the Genome Era: Major Jewish Diaspora Populations Comprise Distinct Genetic Clusters with Shared Middle Eastern Ancestry Gil Atzmon,
How surgeons can find information online? Martin Hewitt International Journal of Surgery Volume 5, Issue 6, Pages (December 2007) DOI: /j.ijsu
The Duty to Recontact: Attitudes of Genetics Service Providers Jennifer L. Fitzpatrick, Cecil Hahn, Teresa Costa, Marlene J. Huggins The American Journal.
PRIMUS: Rapid Reconstruction of Pedigrees from Genome-wide Estimates of Identity by Descent Jeffrey Staples, Dandi Qiao, Michael H. Cho, Edwin K. Silverman,
Peopling of Sahul: mtDNA Variation in Aboriginal Australian and Papua New Guinean Populations Alan J. Redd, Mark Stoneking The American Journal of Human.
The Structure of Common Genetic Variation in United States Populations
Genomic Patterns of Homozygosity in Worldwide Human Populations
Ethiopian Genetic Diversity Reveals Linguistic Stratification and Complex Influences on the Ethiopian Gene Pool  Luca Pagani, Toomas Kivisild, Ayele Tarekegn,
Rapid Simulation of P Values for Product Methods and Multiple-Testing Adjustment in Association Studies  S.R. Seaman, B. Müller-Myhsok  The American Journal.
Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia  Kevin J. Galinsky, Gaurav Bhatia, Po-Ru Loh, Stoyan Georgiev,
CHEK2*1100delC and Susceptibility to Breast Cancer: A Collaborative Analysis Involving 10,860 Breast Cancer Cases and 9,065 Controls from 10 Studies 
2016 Curt Stern Award Address: From Rare to Common Diseases: Translating Genetic Discovery to Therapy1  Brendan Lee  The American Journal of Human Genetics 
Yu Jiang, Glen A. Satten, Yujun Han, Michael P. Epstein, Erin L
Linkage Thresholds for Two-stage Genome Scans
A Combined Linkage-Physical Map of the Human Genome
Haplotypes and Linkage Disequilibrium at the Phenylalanine Hydroxylase Locus, PAH, in a Global Representation of Populations  Judith R. Kidd, Andrew J.
Genetics, Individuality, and Medicine in the 21st Century*
Signatures of Purifying and Local Positive Selection in Human miRNAs
XMCPDT Does Have Correct Type I Error Rates
Gene Expression in Skin and Lymphoblastoid Cells: Refined Statistical Method Reveals Extensive Overlap in cis-eQTL Signals  Jun Ding, Johann E. Gudjonsson,
Variant Association Tools for Quality Control and Analysis of Large-Scale Sequence and Genotyping Array Data  Gao T. Wang, Bo Peng, Suzanne M. Leal  The.
Transethnic Genetic-Correlation Estimates from Summary Statistics
Xiangqing Sun, Robert Elston, Nathan Morris, Xiaofeng Zhu 
Maximizing the Power of Principal-Component Analysis of Correlated Phenotypes in Genome-wide Association Studies  Hugues Aschard, Bjarni J. Vilhjálmsson,
Genetic Evidence for Recent Population Mixture in India
Genomic Dissection of Population Substructure of Han Chinese and Its Implication in Association Studies  Shuhua Xu, Xianyong Yin, Shilin Li, Wenfei Jin,
Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region 
A Weighted False Discovery Rate Control Procedure Reveals Alleles at FOXA2 that Influence Fasting Glucose Levels  Chao Xing, Jonathan C. Cohen, Eric Boerwinkle 
GeMes, Clusters of DNA Methylation under Genetic Control, Can Inform Genetic and Epigenetic Analysis of Disease  Yun Liu, Xin Li, Martin J. Aryee, Tomas J.
Association of MicroRNA Expression with Microsatellite Instability Status in Colorectal Adenocarcinoma  Jonathan S.L. Earle, Rajyalakshmi Luthra, Angela.
Five Years of GWAS Discovery
Hugues Aschard, Bjarni J. Vilhjálmsson, Amit D. Joshi, Alkes L
Johanna Jakobsdottir, Mary Sara McPeek 
Dan-Yu Lin, Zheng-Zheng Tang  The American Journal of Human Genetics 
The SNP Endgame: A Multidisciplinary Approach*
Family-Based Tests of Association in the Presence of Linkage
Shuhua Xu, Wei Huang, Ji Qian, Li Jin 
Erratum The American Journal of Human Genetics
Estimating Genetic Effects and Quantifying Missing Heritability Explained by Identified Rare-Variant Associations  Dajiang J. Liu, Suzanne M. Leal  The.
Female-to-Male Breeding Ratio in Modern Humans—an Analysis Based on Historical Recombinations  Damian Labuda, Jean-François Lefebvre, Philippe Nadeau,
James A. Lautenberger, J. Claiborne Stephens, Stephen J
Society for Investigative Dermatology 2010 Meeting Minutes
Wei Pan, Il-Youp Kwak, Peng Wei  The American Journal of Human Genetics 
Research Snippets Journal of Investigative Dermatology
Reviewer Acknowledgment
L-GATOR: Genetic Association Testing for a Longitudinally Measured Quantitative Trait in Samples with Related Individuals  Xiaowei Wu, Mary Sara McPeek 
Leslie S. Emery, Kevin M. Magnaye, Abigail W. Bigham, Joshua M
Abraham's Children in the Genome Era: Major Jewish Diaspora Populations Comprise Distinct Genetic Clusters with Shared Middle Eastern Ancestry  Gil Atzmon,
Haplotypes and Linkage Disequilibrium at the Phenylalanine Hydroxylase Locus, PAH, in a Global Representation of Populations  Judith R. Kidd, Andrew J.
Harold A. Nieuwboer, René Pool, Conor V. Dolan, Dorret I
Alice S. Whittemore, Jerry Halpern 
Hongyu Zhao, Shuanglin Zhang, Kathleen R
Hannah R. Elliott, David C. Samuels, James A. Eden, Caroline L
Quiz page December 2003 American Journal of Kidney Diseases
Zuoheng Wang, Mary Sara McPeek  The American Journal of Human Genetics 
Genomewide Comparison of DNA Sequences between Humans and Chimpanzees
The Size Distribution of Homozygous Segments in the Human Genome
Presentation transcript:

Genetic Landscape of Eurasia and “Admixture” in Uyghurs Hui Li, Kelly Cho, Judith R. Kidd, Kenneth K. Kidd  The American Journal of Human Genetics  Volume 85, Issue 6, Pages 934-937 (December 2009) DOI: 10.1016/j.ajhg.2009.10.024 Copyright © 2009 The American Society of Human Genetics Terms and Conditions

Figure 1 STRUCTURE Bar Views for K = 2–6 and Contour Plots for K = 2 and K = 6 The contour plots and genetic distance tree are color coded to correspond to the STRUCTURE plots. The significance levels for pairwise comparisons of clusters are given on the K = 6 contour plot (bottom) at the relevant borders. The American Journal of Human Genetics 2009 85, 934-937DOI: (10.1016/j.ajhg.2009.10.024) Copyright © 2009 The American Society of Human Genetics Terms and Conditions

Figure 2 Principal Component Plot of Eurasian Populations Just over 80% of the variance among these populations based on the 68 SNPs in this study can be explained by the first two components. The American Journal of Human Genetics 2009 85, 934-937DOI: (10.1016/j.ajhg.2009.10.024) Copyright © 2009 The American Society of Human Genetics Terms and Conditions