Presentation is loading. Please wait.

Presentation is loading. Please wait.

Transethnic Genetic-Correlation Estimates from Summary Statistics

Similar presentations


Presentation on theme: "Transethnic Genetic-Correlation Estimates from Summary Statistics"— Presentation transcript:

1 Transethnic Genetic-Correlation Estimates from Summary Statistics
Brielin C. Brown, Chun Jimmie Ye, Alkes L. Price, Noah Zaitlen  The American Journal of Human Genetics  Volume 99, Issue 1, Pages (July 2016) DOI: /j.ajhg Copyright © 2016 American Society of Human Genetics Terms and Conditions

2 Figure 1 True and Estimated Genetic-Impact and Genetic-Effect Correlations All simulations were conducted with a simulated EUR and EAS heritability of 0.5 with 4,499 simulated EUR and 4,836 simulated EAS individuals at 248,953 SNPs. The American Journal of Human Genetics  , 76-88DOI: ( /j.ajhg ) Copyright © 2016 American Society of Human Genetics Terms and Conditions

3 Figure 2 The Distributions of the Estimates of Genetic Correlation Computed with Popcorn and GCTA Are Compared The distribution was computed via Gaussian kernel density estimation on the set of genetic-correlation estimates. The American Journal of Human Genetics  , 76-88DOI: ( /j.ajhg ) Copyright © 2016 American Society of Human Genetics Terms and Conditions

4 Figure 3 Genetic Correlation as a Function of Heritability for Gene Expression The mean and SE of the genetic correlation of the set of genes with h12 and h22 exceeding threshold h in each analysis (y axis) are plotted against h (x axis). The American Journal of Human Genetics  , 76-88DOI: ( /j.ajhg ) Copyright © 2016 American Society of Human Genetics Terms and Conditions


Download ppt "Transethnic Genetic-Correlation Estimates from Summary Statistics"

Similar presentations


Ads by Google