1. GWIS: Genome-Wide Inferred Statistics for Functions of Multiple Phenotypes 
Harold A. Nieuwboer, René Pool, Conor V. Dolan, Dorret I. Boomsma, Michel G. Nivard 
The American Journal of Human Genetics 
Volume 99, Issue 4, Pages (October 2016)
DOI: /j.ajhg
Copyright © 2016 American Society of Human Genetics Terms and Conditions

2. Figure 1 Manhattan Plot of BMI GWAS and GWIS
Manhattan plots of −log p values for the (A) BMI GWAS as performed by Randall et al.5, (B) BMI GWIS using male height data, and (C) BMI GWIS using female height data. The location on the x axis corresponds to the genomic location of the SNP. In each figure, the blue line corresponds to p = 1 × 10−5 and the red line corresponds to p = 5 × 10−8.
The American Journal of Human Genetics  , DOI: ( /j.ajhg )
Copyright © 2016 American Society of Human Genetics Terms and Conditions

3. Figure 2
Comparison of BMI GWAS and BMI GWIS Summary Statistics Based on Male Height Data
Scatterplots of BMI GWAS effect sizes versus GWIS (male height) (A) effect sizes, (B) standard errors, and (C) Z scores. The top left corner for each figure reports the squared correlation.
The American Journal of Human Genetics  , DOI: ( /j.ajhg )
Copyright © 2016 American Society of Human Genetics Terms and Conditions

4. Figure 3
Comparison of BMI GWAS and BMI GWIS Summary Statistics Based on Female Height Data
Scatterplots of BMI GWAS effect sizes versus GWIS (female height) (A) effect sizes, (B) standard errors, and (C) Z scores. The top left corner for each figure reports the squared correlation.
The American Journal of Human Genetics  , DOI: ( /j.ajhg )
Copyright © 2016 American Society of Human Genetics Terms and Conditions

5. Figure 4
A Schematic Representation of the Role of GWISs in Relation to Traditional GWASs
A GWIS provides a connection between several GWASs of phenotypes and a GWAS of a function of these phenotypes, without requiring access to the actual phenotypical data.
The American Journal of Human Genetics  , DOI: ( /j.ajhg )
Copyright © 2016 American Society of Human Genetics Terms and Conditions