Supplementation with progestogens in the first trimester of pregnancy to prevent miscarriage in women with unexplained recurrent miscarriage: a systematic.

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Presentation transcript:

Supplementation with progestogens in the first trimester of pregnancy to prevent miscarriage in women with unexplained recurrent miscarriage: a systematic review and meta-analysis of randomized, controlled trials Gabriele Saccone, M.D., Corina Schoen, M.D., Jason M. Franasiak, M.D., Richard T. Scott, M.D., H.C.L.D., Vincenzo Berghella, M.D. Fertility and Sterility Volume 107, Issue 2, Pages 430-438.e3 (February 2017) DOI: 10.1016/j.fertnstert.2016.10.031 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Fertility and Sterility 2017 107, 430-438. e3DOI: (10. 1016/j Fertility and Sterility 2017 107, 430-438.e3DOI: (10.1016/j.fertnstert.2016.10.031) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Forest plot for the risk of recurrent miscarriage in women with unexplained recurrent miscarriage. df = degrees of freedom; M-H = Mantel-Haenszel. Fertility and Sterility 2017 107, 430-438.e3DOI: (10.1016/j.fertnstert.2016.10.031) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Flow diagram of studies identified in the systematic review (PRISMA template). Fertility and Sterility 2017 107, 430-438.e3DOI: (10.1016/j.fertnstert.2016.10.031) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Assessment of risk of bias. (A) Summary of risk of bias for each trial; Plus sign = low risk of bias; minus sign = high risk of bias; question mark = unclear risk of bias. (B) Risk of bias graph about each risk of bias item presented as percentages across all included studies. Fertility and Sterility 2017 107, 430-438.e3DOI: (10.1016/j.fertnstert.2016.10.031) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 3 Funnel plot for assessing publication bias. Fertility and Sterility 2017 107, 430-438.e3DOI: (10.1016/j.fertnstert.2016.10.031) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions