What does this protein make up or do? Chapter 14: Chromosome 14 DNA Sequence Chromosome 87257 bp Name of Protein 14 Name of Gene Precilin 1 PSEN1 transcription Amino acid sequence mRNA 378 aa translation Cytoplasm A Cell Nucleus What does this protein make up or do? When PSEN1 is working incorrectly it mutations amyloid precursor protein and they can lead to Alzheimer's. Condition/Disease Alzheimer's

Description of Alzheimer's Symptoms: 1. Memory loss that effects daily life. 2. Confusion with time or place. Characteristics 3. Memory loss Normal Vision As viewed by a person with glaucoma Pictures used with permission from URL: http://www.nei.nih.gov/health/glaucoma/glaucoma_facts.asp

Description of Alzheimer's (cont.) Who is affected? People over the age of 65 Studies have shown that women tend to be diagnosed with Alzheimer's then men do. Passed down through genes Head injury Outlook or quality of life No known cure yet Tends to get worse as you age Tend to need care as the disease gets worse. Researcher: AW

References http://www.alzheimer- europe.org/Dementia/Alzheimer-s-disease/Main- characteristics-of-Alzheimer-s-disease?#fragment-1 http://www.alz.org/alzheimers_disease_10_signs_of_alz heimers.asp https://www.google.com/#q=who%20can%20be%20a ffected%20by%20alzheimer%27s http://ghr.nlm.nih.gov/gene/PABPN1 http://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&do pt=full_report&list_uids=5663 http://ghr.nlm.nih.gov/gene/PSEN1