1. Chapter 2: Chromosome 2 2 A Cell Nucleus 728,838 1620 aa ALK Cytoplasm
DNA Sequence
Chromosome
728,838
Name of Protein 2
Name of Gene
Anaplastic Lymphoma Kinase
ALK
transcription
Amino acid sequence
mRNA
1620 aa
translation
Cytoplasm
A Cell
Nucleus
What does this protein make up or do?
provides instructions for making a protein called anaplastic lymphoma kinase, part of a family of proteins called receptor tyrosine kinases (RTKs).
Condition/Disease
Anaplstic Lymphoma Kinase

2. Description of ALK Symptoms and characteristics
The ALK gene belongs to a family of genes called CD (CD molecules).
Neuroblastoma occurs when immature nerve cells called neuroblasts become abnormal and multiply uncontrollably to form a tumor.
Individuals with neuroblastoma may develop general signs and symptoms such as irritability, fever, tiredness (fatigue), pain, loss of appetite, weight loss, or diarrhea. More specific signs and symptoms depend on the location of the tumor and where it has spread.
Normal Vision
How the disease looks inside your body

3. Description of ALK (cont.)
Who is affected?
Neuroblastoma is a type of cancer that most often affects children. Neuroblastoma occurs when immature nerve cells called neuroblasts become abnormal and multiply uncontrollably to form a tumor.
Neuroblastoma occurs most often in children before age 5 and rarely occurs in adults.
Outlook or quality of life
Neuroblastoma can spread (metastasize) to other parts of the body such as the bones, liver, or skin.
This disease can be inherited but not all the time
There is no cure for this disease
Researcher : SD

4. References http://ghr.nlm.nih.gov/gene/ALK