1. Chapter 13: Chromosome 13 BCCIP mRNA transcription translation Amino acid sequence Name of Protein DNA Sequence Name of Gene Chromosome What does this protein make up or do?it contains several copies of a 70 aa motif called BRC Motif and these motif mediate binding to the RAD51 recombinase which function s in DNA REPAIR Condition/Disease BRCA2 13 11,385 bp 3418aa may cause increased pressure in the eye by obstructing the aqueous outflow Breast cancer

2. Description of Glaucoma Symptoms and characteristics Symptoms and characteristics Itchy, scaly sore or rash on the nipple of the breast and swelling,warmth, redness or darkening of the breast. Dimpling or puckering of the skin of the breast 1. The body system affected is the breast. 2. Screening tests (such as yearly mammograms) are given routinely to people who appear to be healthy and are not suspected of having breast cancer. Normal Vision As viewed by a person with glaucoma Pictures used with permission from URL: http://www.nei.nih.gov/health/glaucoma /glaucoma_facts.asp

3. Description of Glaucoma (cont.) Who is affected? Anyone, but the following have a higher ri sk. Who is affected? Anyone, but the following have a higher ri sk. Breast cancer is much more common in women than in men. Breast cancer is much more common in women than in men. People who have inherited mutation in certain genes like BRCA2 and BRCA1 are at high risk of getting breast cancer. People who have inherited mutation in certain genes like BRCA2 and BRCA1 are at high risk of getting breast cancer. White woman are silently more likely to get breast cancer than African American women.Africa American women though are more likely to die of breast cancer. White woman are silently more likely to get breast cancer than African American women.Africa American women though are more likely to die of breast cancer. Outlook or quality of life Outlook or quality of life Without treatment, you can die and go bald. Without treatment, you can die and go bald. With treatment, you will get a life support to live longer. With treatment, you will get a life support to live longer. Treatments include medicine, Chemotherapy, radiation therapy and surgery.radiation therapy. Treatments include medicine, Chemotherapy, radiation therapy and surgery.radiation therapy. Researcher: CA Researcher: CA Radiation therapy Radiation therapy

4. References National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Genetic/Familial High-Risk Assessment: Breast and Ovarian. Version 4;2013.2. 2. Pal T, Permuth-Wey J, Betts JA, et al. BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases. Cancer. 2005;104(12):2807- 2816. 3 National Cancer Institute. BRCA1 and MRCA2: Cancer risk and genetic testing. http://www.cancer.gov/cancertopics/factsheet/Risk/BRCA. Accessed June 2, 2014. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Genetic/Familial High-Risk Assessment: Breast and Ovarian. Version 4;2013.2. 2. Pal T, Permuth-Wey J, Betts JA, et al. BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases. Cancer. 2005;104(12):2807- 2816. 3 National Cancer Institute. BRCA1 and MRCA2: Cancer risk and genetic testing. http://www.cancer.gov/cancertopics/factsheet/Risk/BRCA. Accessed June 2, 2014. http://ghr.nlm.nih.gov/gene/BRCA2 http://ghr.nlm.nih.gov/gene/BRCA2 http://ghr.nlm.nih.gov/gene/BRCA2 National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USAhttp://www.ncbi.nlm.nih.gov/protein/?term=BRCA2%20Gen e National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USAhttp://www.ncbi.nlm.nih.gov/protein/?term=BRCA2%20Gen e National Center for Biotechnology InformationU.S. National Library of Medicine National Center for Biotechnology InformationU.S. National Library of Medicine.