1. What does this protein make up or do? Charcot–Marie–Tooth disease
Chapter 10: Chromosome 10
DNA Sequence
Chromosome
35,581
Name of Protein 10
Name of Gene
periphal myelin
PMP22
transcription
Amino acid sequence
mRNA
160 aa
Cytoplasm
translation
What does this protein make up or do?
A Cell
Nucleus
Involved in growth regulation in myelination in the peripheral nervous system
Condition/Disease
Charcot–Marie–Tooth disease

2. Description of : Charcot–Marie–Tooth disease
Symptoms and characteristics
-Charcot (shahr-KOH)-Marie-Tooth disease is a group of hereditary disorders that damage the nerves in your arms and legs (peripheral nerves).
-If foot deformities are severe, corrective foot surgery may help alleviate pain and improve your ability to walk. But surgery can't improve weakness or loss of sensation
-Complications of Charcot-Marie-Tooth disease vary in severity from person to person, with foot abnormalities and difficulty walking generally being the most serious problems. Muscle weakness may also increase, and injury to areas of the body with decreased sensation may occur.
-Charcot–Marie–Tooth disease can be detected through a physical exam.

3. Description of: Charcot–Marie–Tooth disease (cont.)
Who is affected? Anyone, but the following have a higher risk:
-Symptoms of Charcot-Marie-Tooth disease typically appear in adolescence or early adulthood, but this condition can develop in midlife too.
Outlook or quality of life
-There's no cure for Charcot-Marie-Tooth disease. But, the disease generally progresses slowly, and the expected length of life isn't shortened by the disorder.
Researcher: BH

4. References 1. 2. 3.