a b c d Supplemental Figure S x108 IFU 2x108 IFU 28 28

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a b c d Supplemental Figure S4 35 35 2x108 IFU 2x108 IFU 28 28 average animal weight (grams) average animal weight (grams) 21 21 PBS Ad5WT HIF-Ad-IL4 PBS Ad5WT HIF-Ad HIF-Ad-IL4 14 14 25 33 40 49 57 64 67 23 26 28 33 37 40 43 46 50 54 56 Day post-tumor cell implantation Day post-tumor cell implantation c d 35 35 1x106 IFU 5x107 IFU 28 28 average animal weight (grams) average animal weight (grams) 21 21 PBS HYPR-Ad-IL4 PBS HYPR-Ad#1 HIF-Ad HIF-Ad-IL4 14 14 35 42 46 49 53 57 60 64 45 69 Day post-tumor cell implantation Day post-tumor cell implantation Supplemental Figure S4