1. CDV potentiates the antitumor effect of ionizing radiation in mice intracerebrally implanted with human glioblastoma cells.
CDV potentiates the antitumor effect of ionizing radiation in mice intracerebrally implanted with human glioblastoma cells. Tumor bioluminescence (A and C) and animal survival (B and D) of athymic mice treated with CDV only, radiation only, or with concurrent radiation and CDV therapy. Bioluminescence results (means ± SD) are at days 26 (U87MG; A) and 29 (SF7796; C) post tumor cell implantation. Values of the Student t test are indicated for all two-way comparison (*, P < 0.05). CDV treatments were as described in the Materials and Methods section, and were initiated at day 11 post U87MG (B), and at day 19 post SF7796 cell (D) implantation. Radiotherapy involved treatment with 2 Gy/d for 5 consecutive days, beginning at days 11 and 19 post U87MG and SF7796 implantation, respectively.
Piotr Hadaczek et al. Clin Cancer Res 2013;19:
©2013 by American Association for Cancer Research