Identification of combination treatment–responsive dysfunctional tumor-infiltrating CD8+ T cell population. Identification of combination treatment–responsive.

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Identification of combination treatment–responsive dysfunctional tumor-infiltrating CD8+ T cell population. Identification of combination treatment–responsive dysfunctional tumor-infiltrating CD8+ T cell population. (A) Density viSNE plots of OVA-specific intratumoral CD8+ T cells from each treatment group days 9 and 12 after tumor challenge. (B) viSNE plots of tumor-infiltrating T cells overlaid with the expression of indicated markers. (C) viSNE plot of intratumoral OVA-specific CD8+ T cells overlaid with color-coded T cell clusters identified by SPADE. (D) Frequency of selected T cell clusters displayed on a per-mouse basis with means ± SEM. Indicated cluster was highlighted on viSNE plot below the bar graph. (E) Histogram displaying the expression level of indicated markers on T cell clusters. (F) CITRUS cluster result overlaid with indicated markers. Cluster that was significantly affected with Ab treatment is circled (C1). (G) Frequency of cluster C1 is shown with means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, one-way ANOVA test. Bei Wang et al. Sci. Immunol. 2018;3:eaat7061 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works