IL-12 and IL-23

Introduction

IL-23/T17-Mediated Effects on Epidermal Keratinocytes in Psoriatic Disease

Role of IL-23/IL-17 Axis in Driving Enthesitis

Role of IL-12 and IL-23 in Chronic Intestinal Inflammation

Genetic and Pathophysiology Overlap of Spondyloarthropathies and Related Conditions

Clinical Overlap Between Immunoinflammatory Disorders of Skin, Joints, and Gut

Therapeutic Approaches

Key Clinical Data in Psoriasis

Key Clinical Data in Psoriasis (Cont)

Role of Selective IL-23 p19 Targeting

Key Clinical Data in PsA

Key Clinical Data in Crohn Disease

Role of Real-World Data vs Randomized Clinical Trials

Drug Survival and Safety of Ustekinumab From Psoriasis Real-World Data

Drug Survival From Psoriasis Real-World Data

Drug Survival From Psoriasis Real-World Data (Cont)

Drug Survival From Psoriasis Real-World Data (Cont)

Drug Survival From Psoriasis Real-World Data (Cont)

Drug Survival From PsA Real-World Data

Management of Patients With Immune-Mediated Inflammatory Diseases

Management of Patients With Immune-Mediated Inflammatory Diseases (cont)

Future Biologics Targeting IL-23

Conclusions

Abbreviations

Abbreviations (cont)