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Understanding Comparative Effectiveness Data in Psoriatic Arthritis

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Presentation on theme: "Understanding Comparative Effectiveness Data in Psoriatic Arthritis"— Presentation transcript:

1 Understanding Comparative Effectiveness Data in Psoriatic Arthritis

2

3 Evolving Complexity of the Biologic Treatment Landscape for PsA

4 Treatment Schema for Active PsA: GRAPPA

5 Comparison of EULAR and GRAPPA Recommendations

6 Secukinumab in PsA: FUTURE 5 Clinical Trial

7 Tofacitinib in PsA: OPAL Clinical Trials

8 How Can Clinicians Make Treatment Decisions?

9 Real-World Evidence

10 Randomized Control Trials vs Real-World Evidence

11 How Can Clinicians Make Treatment Decisions? (cont)

12 MAIC: The Why and the How

13 Anchored and Unanchored Analyses

14 Comparison of Methods: Summary of Pros and Cons

15 NICE Recommendations for Comparative Effectiveness

16 Key Takeaways From NMA Studies

17 Key Takeaways From NMA Studies (cont)

18 MAIC: Methodology

19 MAIC: Methodology (cont)

20 ADA vs ETA vs INF

21 ADA vs SEC: ADEPT vs Pooled FUTURE 1 and 2

22 ADA vs SEC: ADEPT vs Pooled FUTURE 1 and 2 (cont)

23 SEC vs ADA: Pooled FUTURE 1 and 2 vs ADEPT

24 SEC vs ADA: Pooled FUTURE 1 and 2 vs ADEPT (cont)

25 SEC vs ADA: FUTURE 2 vs ADEPT

26 SEC vs ADA: FUTURE 2 vs ADEPT (cont)

27 SEC vs INF: Pooled FUTURE 1 and 2 vs IMPACT 2

28 SEC vs INF: Pooled FUTURE 1 and 2 vs IMPACT 2 (cont)

29 Clinical Insights Based on the Totality of Evidence

30 Therapeutic Landscape for PsA Is Expanding

31 Ongoing Head-To-Head Studies

32 Conclusions

33 Abbreviations

34 Abbreviations (cont)

35 Abbreviations (cont)


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