Role of cAMP-responsive element modulator-τ (CREMτ) in ipsilateral testicular injury after unilateral testicular torsion-detorsion Si-Ming Wei, M.D.,

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Role of cAMP-responsive element modulator-τ (CREMτ) in ipsilateral testicular injury after unilateral testicular torsion-detorsion Si-Ming Wei, M.D., Ph.D., Zhi-Zhong Yan, M.S., Jian Zhou, M.D. Fertility and Sterility Volume 89, Issue 6, Pages 1737-1742 (June 2008) DOI: 10.1016/j.fertnstert.2007.04.044 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Rat testicular weight (A), mean seminiferous tubular diameter (B), number of germ cell layers (C), mean testicular biopsy score (D), and expressions of CREMτ mRNA (E) and protein (F) in control and torsion-detorsion (T/D) groups 3 months after detorsion. Hatched bars show the ipsilateral testes; open bars show the contralateral testes. ∗Value significantly different from that of control group (P<.05). #Value significantly different from that of contralateral testis in the same group (P<.05). Fertility and Sterility 2008 89, 1737-1742DOI: (10.1016/j.fertnstert.2007.04.044) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Testicular histology 3 months after detorsion. (hematoxylin and eosin staining, original magnification ×100 in panels A and C and ×400 in panels B and D). (A, B) The bilateral testes in the control group and contralateral testes in the torsion-detorsion group all indicated normal seminiferous tubular diameter and the number of germ cell layers (A) and the presence of many elongated spermatids (arrowheads) and spermatozoa (arrows) in tubular lumen (B). (C, D) Ipsilateral testes in the torsion-detorsion group showed seminiferous tubular atrophy and reduction of germ cell layers number (C); the germ cells only developed to the early spermatid stage, that is, the round spermatid stage (arrows), and elongated spermatids and spermatozoa were absent (D). Fertility and Sterility 2008 89, 1737-1742DOI: (10.1016/j.fertnstert.2007.04.044) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Analysis of CREMτ expressions in rat testes in the control and torsion-detorsion groups 3 months after detorsion. (A) RT-PCR analysis of CREMτ mRNA expression. (B) Western blot analysis of CREMτ protein expression. M = marker; N = negative control (using water as a substitute for cDNA); lanes 1L and 1R = left (i.e., ipsilateral) and right (i.e., contralateral) testes in the control group; lanes 2L and 2R = ipsilateral and contralateral testes in the torsion-detorsion group. Compared with the control group, expressions of CREMτ mRNA and protein were obviously reduced in the ipsilateral testes of the torsion-detorsion group but not in the contralateral testes of the torsion-detorsion group. Fertility and Sterility 2008 89, 1737-1742DOI: (10.1016/j.fertnstert.2007.04.044) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions