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Low-dose mifepristone increases uterine natural killer cell cytotoxicity and perforin expression during the receptive phase  Feng Zhou, M.M., Xiu-Ying.

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Presentation on theme: "Low-dose mifepristone increases uterine natural killer cell cytotoxicity and perforin expression during the receptive phase  Feng Zhou, M.M., Xiu-Ying."— Presentation transcript:

1 Low-dose mifepristone increases uterine natural killer cell cytotoxicity and perforin expression during the receptive phase  Feng Zhou, M.M., Xiu-Ying Chen, M.M., Ya-Ling Zhuang, M.D., Yue-Zhou Chen, M.D., Li-Li Huang, M.D.  Fertility and Sterility  Volume 96, Issue 3, Pages (September 2011) DOI: /j.fertnstert Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Morphological characteristics of endometrium before and after culture with mifepristone. Sections of endometrial explants were stained with hematoxylin and eosin (H & E) before culture (A), or after 24 hours in culture with 0 (B), 65 (C), and 200 nmol/L mifepristone (D). Magnification, ×200. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Comparative analysis of the effects of mifepristone on expression of perforin by uterine natural killer cells during the receptive phase. Perforin (black) expression was localized in the cytoplasm and CD56 (red) expression was localized on the cell membrane of endometrial explants after 24 hours in culture with 0 (A), 65 (B), and 200 nmol/L mifepristone (C). Cells double-labeled with antibodies against perforin and CD56 are indicated with white arrows. Magnification, ×400. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions


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