Supplemental PowerPoint Slides The Basis of Mechanical Instability in Degenerative Disc Disease: A Cadaveric Study of Abnormal Motion vs. Load Distribution. Author: Dilip K. Sengupta MD, Dr. Med Associate Professor Department of Orthopedics Dartmouth-Hitchcock Medical Center One Medical Center Drive Lebanon NH 03756 Contact: E-mail: dksg@hotmail.com Phone: 603 369 1281 Author: Haibo Fan PhD Senior Research Associate Biomechanics Laboratory Copyright © 2012 Lippincott Williams & Wilkins. Unauthorized commercial reproduction of this slide is prohibited

Sp 61317 I L1 II L2 II L3 III L4 III L5 IV S1

* 296 ±115 * * 250 ±70 231 ±66 227 ±144 * 192 ±164 * 189 ±129 173 ±102 161 ±108 153 ±97 104 ±76 68 ±83 26 ±53 Figure 8. Mean nuclear pressure (+/- SD) measured from the central 1/3 of the disc space from intra-discal pressure profiles. The difference was found statistically significant (*) in Extension: I-III and I-IV, Flexion: I-IV, Neutral: I-IV and III-IV