Transfer of RNA molecules serve as interpreters during translation

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Transfer of RNA molecules serve as interpreters during translation Amino acids that are to be joined in correct sequences cannot recognize the codons on the mRNA. Transfer RNA (tRNA) molecules, one or more for each type of amino acid to the right codon. Each tRNA contains a region (the anticodon) that recognizes and binds to the correct codon on the mRNA.

Ribosomes build polypeptides Ribosomes are composed of ribosomal RNA (rRNA) and protein, arranged in two subunits. The shape of ribosomes provides a platform on which protein synthesis can take place. There are locations for the mRNA, and two tRNA-amino acid complex binding sites (an A site and a P site).

An initiation codon marks the start of an mRNA message Translation can be divided into the same three phases as transcription: initiation, elongation, and termination. An mRNA molecule is longer than the genetic message it contains. It contains a starting nucleotide sequence that helps the initiation phase and an ending sequence that helps the termination phase. During initiation, the initial sequence helps bind the mRNA to the ribosomal subunit, a specific start codon binds with an initiator tRNA anticodon carrying the amino acid methionine, and the large ribosome binds to the small subunit as the initiator tRNA fits into the P site on the large subunit.

Elongation adds amino acids to the polypeptide until a stop codon terminates translation Elongation involves three steps (a) codon recognition (b) peptide bond formation (c) translocation The formation of the polypeptide bond is catalyzed by an enzyme within the ribosome structure. Elongation continues until a special stop codon (UAA, UAG, or UGA) causes termination of the process. The finished polypeptide is freed, and the ribosome splits into its two subunits.

Elongation

Termination

Mutations can change the meaning of genes Many differences in inherited traits in humans have been traced to their molecular causes. A change in the nucleotide sequence of DNA is known as a mutation. Certain substitutions of one nucleotide base for another will lead to mutations, resulting in the replacement of one amino acid for another in a polypeptide sequence. Base substitutions usually cause a gene to produce an abnormal product, or they result in no change if the new codon still codes for the same amino acid. A base substitution is known to account for the type of hemoglobin produced by the sickle-cell allele.

Sickle-Cell

Rarely, base substitutions lead to improved or changed genes that may enhance the success of the individual in which they occur. The addition or subtraction of nucleotides may result in a shift of the three-base reading frame; all codons past the affected one are likely to code for different amino acids. The differences that result will almost always result in a nonfunctional polypeptide.