Clinical disease due to enterovirus D68 in adult hematologic malignancy patients and hematopoietic cell transplant recipients by Alpana Waghmare, Steven.

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Clinical disease due to enterovirus D68 in adult hematologic malignancy patients and hematopoietic cell transplant recipients by Alpana Waghmare, Steven A. Pergam, Keith R. Jerome, Janet A. Englund, Michael Boeckh, and Jane Kuypers Blood Volume 125(11):1724-1729 March 12, 2015 ©2015 by American Society of Hematology

Flowchart of the EV-D68 testing algorithm. Flowchart of the EV-D68 testing algorithm. Presumptive EV-D68: EV-D68 PCR cycle threshold (CT) values at least 4 cycles lower than the HRV CT (for HRV-positive samples) or any EV-D68 CT value (for HRV negative samples). Proven EV-D68: confirmed by sequencing. RV, respiratory viruses. Alpana Waghmare et al. Blood 2015;125:1724-1729 ©2015 by American Society of Hematology

Selected radiographic images from patients with presumptive EV-D68 infection. Selected radiographic images from patients with presumptive EV-D68 infection. (A) Case 2, day −3 CT: ground glass opacities and nodule airspace opacities throughout, and consolidation in lingula and L lower lobe. (B) Case 2, day +3 chest radiograph (CXR): diffuse L lung disease and patchy R lung disease; possible bilateral pleural effusion. (C) Case 2, day +18 CT: worsening ground-glass L upper lobe, and patchy ground-glass R right upper and middle lobes. (D) Case 3, day −1 CT: patchy consolidation R lower lobe, and nodules in both lower lobes; mild interlobular septal thickening. (E) Case 3, day +4 CXR: bilateral basilar consolidation. (F) Case 7, day +1 CXR: increased left pleural effusion with underlying atelectasis; increased right lower lobe consolidation. (G) Case 7, day +4 CT: interval increase R pleural effusion; large L pleural effusion. New patchy consolidation R middle lobe; bilateral lower lobe consolidation. Alpana Waghmare et al. Blood 2015;125:1724-1729 ©2015 by American Society of Hematology