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Rubinowitz Ami N. , MD, Moon Marianne , MD, Homer Robert , MD, PhD 

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Presentation on theme: "Rubinowitz Ami N. , MD, Moon Marianne , MD, Homer Robert , MD, PhD "— Presentation transcript:

1 A 34-Year-Old Man Presenting With Gradual Onset of Shortness of Breath and Interstitial Lung Disease 
Rubinowitz Ami N. , MD, Moon Marianne , MD, Homer Robert , MD, PhD  CHEST  Volume 133, Issue 4, Pages (April 2008) DOI: /chest Copyright © 2008 The American College of Chest Physicians Terms and Conditions

2 Figure 1 Posteroanterior chest radiograph demonstrates mild increased interstitial markings in the lower lobes. CHEST  , DOI: ( /chest ) Copyright © 2008 The American College of Chest Physicians Terms and Conditions

3 Figure 2 Transverse high-resolution CT image obtained through the mid-chest at the level of the hila shows bilateral, subpleural areas of ground-glass opacity with minimal fine reticular markings. CHEST  , DOI: ( /chest ) Copyright © 2008 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Transverse high-resolution CT image obtained through the lower one third of the chest at the level of the inferior pulmonary veins shows bilateral patchy areas of ground-glass opacity with subpleural sparing in the lower lobes, and mild traction bronchiectasis (arrows) in the middle lobe. CHEST  , DOI: ( /chest ) Copyright © 2008 The American College of Chest Physicians Terms and Conditions

5 Figure 4 Transverse CT image obtained through the lower one third of the chest (at a comparable level as in Fig 3) following 6 months of treatment with prednisone and cytoxan shows dramatic improvement of ground-glass opacity with minimal residual ground-glass density and mild architectural distortion remaining. CHEST  , DOI: ( /chest ) Copyright © 2008 The American College of Chest Physicians Terms and Conditions

6 Figure 5 Medium power view of lung shows a diffuse expansion of the interstitium with a mixture of loose fibrosis, inflammation, and mild interstitial fibrosis (hematoxylin-eosin, original × 20). CHEST  , DOI: ( /chest ) Copyright © 2008 The American College of Chest Physicians Terms and Conditions


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