1. Acute chest syndrome of sickle cell disease
Acute chest syndrome of sickle cell disease. A 27-year-old man with sickle cell disease presented with fever, shortness of breath, and vaso-occlusive crisis with left chest wall pain. A chest radiograph on day 3, initially normal on day 1, demonstrates the development of a bilateral lower lobe infiltrate and bilateral pulmonary volume loss. Chest computed tomographic images on day 3 show bilateral basilar infiltrates, with dense consolidation of left lower lobe, and small bilateral pleural effusions. Micrographs after oil red O staining (which stains fat red) of specimens obtained by bronchoalveolar lavage showed lipid-laden macrophages consistent with the acute chest syndrome caused by bone marrow fat embolism to lung. (Haley M, Gladwin MT, unpublished observations.)
Source: Sickle Cell Disease, Principles of Critical Care, 4e
Citation: Hall JB, Schmidt GA, Kress JP. Principles of Critical Care, 4e; 2015 Available at: Accessed: October 22, 2017
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