From: Systematic Reviews of Diagnostic Test Accuracy

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Systematic reviews and meta-analyses of diagnostic test accuracy

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From: Systematic Reviews of Diagnostic Test Accuracy Ann Intern Med. 2008;149(12):889-897. doi:10.7326/0003-4819-149-12-200812160-00008 Figure Legend: Review authors' judgments about quality items in a systematic review of magnetic resonance imaging for multiple sclerosis.Data from reference 31. Data are presented as the proportion of included studies. Criteria that are unclear or not met introduce a risk for bias. The authors considered the relative lack of an acceptable reference standard as the main weakness of the review. Date of download: 11/12/2017 Copyright © American College of Physicians. All rights reserved.

From: Systematic Reviews of Diagnostic Test Accuracy Ann Intern Med. 2008;149(12):889-897. doi:10.7326/0003-4819-149-12-200812160-00008 Figure Legend: Summary receiver-operating characteristic (ROC) curve plots showing test accuracy of a tumor marker for bladder cancer from 8 studies included in a systematic review.Data from reference 10. Each study is represented by a small box positioned at the estimated sensitivity and specificity. The height and width of each box are proportional to the numbers of patients with and without bladder cancer, respectively, in each study. Top. This panel shows the summary ROC curve that can be drawn through these values. The scatter of the points fit, to a degree, with the existence of a threshold-type relationship between sensitivity and specificity. The curve is an estimate of the underlying relationship between sensitivity and specificity for the test used across varying thresholds. Bottom. This panel shows the average sensitivity and specificity estimate of the study results (solid circle) and a 95% confidence region around it. Estimation of a summary point only makes sense when the included studies have used a common threshold. The curves, points, and confidence regions can be estimated by using either the hierarchical summary ROC curve model (36, 54–56) or the bivariate random-effects model (53, 57). Date of download: 11/12/2017 Copyright © American College of Physicians. All rights reserved.

From: Systematic Reviews of Diagnostic Test Accuracy Ann Intern Med. 2008;149(12):889-897. doi:10.7326/0003-4819-149-12-200812160-00008 Figure Legend: Paired forest plot of the sensitivity and specificity of a tumor marker for bladder cancer.FN = false-negative; FP = false-positive; TN = true-negative; TP = true-positive. Data are from reference 10. Forest plots document the extracted data for each study (numbers of TP, FP, FN, and TN results) together with estimates of sensitivity and specificity accompanied by 95% CIs. The scatter of the estimates and CIs indicates that the variability in sensitivity and specificity is unlikely to be explained by chance only, but it is not possible to ascertain whether a threshold-type relationship is evident. Date of download: 11/12/2017 Copyright © American College of Physicians. All rights reserved.

From: Systematic Reviews of Diagnostic Test Accuracy Ann Intern Med. 2008;149(12):889-897. doi:10.7326/0003-4819-149-12-200812160-00008 Figure Legend: Meta-analysis of the diagnostic test accuracy of 2 index tests for bladder cancer: cytology (black squares) and bladder tumor antigen (green diamonds).Data are from reference 10. The meta-analysis is restricted to studies that made a direct comparison between the tests by using both tests in each patient and comparing them with the reference standard of invasive cystoscopy. Restriction of the meta-analysis to direct test comparisons reduces concerns of confounding and allows stronger inferences to be drawn from the comparison of tests. The dashed lines link together the cytology and bladder tumor antigen results from each study and give the impression that bladder tumor antigen is much more sensitive but less specific than cytology. Top. Summary receiver-operating characteristic curves fitted to the data indicate that the bladder tumor antigen curve dominates the cytology curve as specificity decreases. Thus, bladder tumor antigen has the potential to be a more sensitive test than cytology, but only at specificities below 90%. Bottom. Cytology has an average sensitivity of 0.43 and an average specificity of 0.94 (black circle); bladder tumor antigen has an average sensitivity of 0.78 and an average specificity of 0.74 (green circle). The nonoverlapping 95% confidence regions indicate that the differences between the tests are unlikely to have occurred by chance alone. Date of download: 11/12/2017 Copyright © American College of Physicians. All rights reserved.