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Volume 67, Issue 6, Pages (June 2015)

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1 Volume 67, Issue 6, Pages 1112-1121 (June 2015)
Use of the Prostate Imaging Reporting and Data System (PI-RADS) for Prostate Cancer Detection with Multiparametric Magnetic Resonance Imaging: A Diagnostic Meta- analysis  Esther H.J. Hamoen, Maarten de Rooij, J. Alfred Witjes, Jelle O. Barentsz, Maroeska M. Rovers  European Urology  Volume 67, Issue 6, Pages (June 2015) DOI: /j.eururo Copyright © 2014 European Association of Urology Terms and Conditions

2 Fig. 1 Flow diagram for study inclusion.
European Urology  , DOI: ( /j.eururo ) Copyright © 2014 European Association of Urology Terms and Conditions

3 Fig. 2 Graph showing the risk of bias and applicability concerns. Judgments of the review authors for each domain presented as a percentage of the studies included. European Urology  , DOI: ( /j.eururo ) Copyright © 2014 European Association of Urology Terms and Conditions

4 Fig. 3 Summary of the risk of bias and applicability concerns. Judgments of the review authors for each domain for each study included as listed in Table 1. European Urology  , DOI: ( /j.eururo ) Copyright © 2014 European Association of Urology Terms and Conditions

5 Fig. 4 Hierarchic summary receiver operating characteristic (ROC) plot (solid line) plot and summary point (●) with 95% confidence interval (circled area). The dashed line is the line of no discrimination line (area under the curve of 0.5, meaning a worthless test). Squares denote data from individual studies included in the meta-analysis, with the size of each square indicating the relative size of the study population. European Urology  , DOI: ( /j.eururo ) Copyright © 2014 European Association of Urology Terms and Conditions

6 Fig. 5 Forest plots of pooled estimates for all studies overall and for different subgroups. PI-RADS=Prostate Imaging Reporting and Data System. Horizontal lines indicate 95% confidence intervals (CIs). European Urology  , DOI: ( /j.eururo ) Copyright © 2014 European Association of Urology Terms and Conditions

7 Fig. 6 Linear regression test of funnel plot asymmetry. The statistical nonsignificance (p=0.36) for the slope coefficient suggests a low likelihood of publication bias. Numbers in the data circles indicate the study numbers as listed in Table 1. European Urology  , DOI: ( /j.eururo ) Copyright © 2014 European Association of Urology Terms and Conditions


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