Antitussives Tolu balsam

Vasaka is an Antitussive drug Recap In the last class we learnt about Vasaka is an Antitussive drug Vasaka contains Quinazoline alkaloids Vasicine, Vasicinone etc., Expectorant and Bronchodilator activity

OBJECTIVES On completion of this period you would be able to learn about The monograph of the Antitussive drug TOLU BALSAM

Antitussives Agents used in the symptomatic control of Cough Depress the cough centre present in the Medulla Also termed as Anodyne, Cough suppressants and Centrally acting Antitussives

Tolu Balsam Biological Source : Resin obtained by incisions from the trunk of Myroxylon balsamum & Myroxylan toluifera Family : Leguminosae Geographical Source : Native of Columbia Abundant near the river Magdalena and coast San Salvador The name TOLU derived from the place near Cartegena

Balsam Of Tolu: Myroxylan Balsamum Fig.39.1 Tolu balsam tree, twig dried balsam and trunk

Morphological Characters BALSAM Nature : Soft, resinous, semi-solid mass on standing turns brittle and dark Color : Agreeable and fragrant Taste : Aromatic, balsamic, on chewing forms plastic mass Solubility: Soluble in alcohol, acetone and chloroform and partly soluble in carbon disulphide Fig.39.2 Twig

Standards Acid value : 100-160 Reaction : Alcoholic solution acidic to litmus Ester value : 40-95 Saponification value : 170-230 Loss on drying : Not more than 4% Alcohol insoluble matter : Not more than 5%

Chemical Constituents Major constituents: Resin(80%): free Cinnamic acid (contains) free Benzoic acid Resin alcohols combined with acids Toluresinotannol Tolu balsam oil: composed of Phellandrene Benzyl benzoate Benzyl cinnamate Vanillin Eugenol Fig.39.3 Tolu balsam

Identification Tests 1. 90% alcoholic Solutionn + Fecl3 solution Green colour 2. 1gm of Tolu balsam + 5ml water Boil, filter add KMnO4 and heat Odour of Benzaldehyde

Uses Used as Antiseptic, Stimulant and Expectorant Ingredient of Cough mixtures, Tolu balsam syrup and Tolu balsam tincture Ethanolic extract has Antibacterial activity against Mycobacterium tuberculosis Oil of Tolu balsam is used in perfumes, cosmetics, soaps and confectioneries

Summary In this class we discussed about The plant drug TOLU BALSAM which can be used as an Antitussive agent Tolu balsam mainly contain resinous substances Having expectorant and anti-tussive activity

Quiz 1. The active constituents in Tolu balsam are a) Resins b) Alkaloids c) Saponins d) Glycosides

Quiz 2. Tolu balsam belongs to the family a) Annonaceae b) Leguminosae c) Rubiaceae d) Apocyanaceae

Frequently Asked Questions Write the Biological Source and Macroscopic characters of Tolu balsam Mention the Chemical Constituents and Uses of Tolu balsam Write the Botanical Source, Chemical Constituents and Uses of Tolu balsam

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