Chapter 14: Chromosome 14 mRNA transcription translation Amino acid sequence Name of Protein DNA Sequence Name of Gene Chromosome What does this protein make up or do? Condition/Disease PSEN ,257 presenilin aa Carries out the major function of the complex, which is to cut apart (cleave) other proteins into smaller pieces called peptides Alzheimer Disease

Description of Alzheimer’s ■ Symptoms and characteristics ■ Alzheimer Disease is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually even the ability to carry out the simplest tasks of daily living. ■ If you have Alzheimer, you may be the first person to notice you have unusual difficulty remembering things and thoughts. ■ The average life expectancy for people with Alzheimer’s Disease is 10 to 8 years after diagnosis. In some cases I can be short as 3 year or as long as 20 years. content/uploads/2010/03/alzheimers -frontpage1.jpg

Description of Alzheimer's ■ Who is affected? Anyone, but the following have a higher risk: ■ Primarily people over age 65 ■ Nearly half of all individuals who reach the age 85 will develop Alzheimer's. ■ Outlook or quality of life ■ Research shows that by million to 16 million people will have Alzheimer's. ■ Alzheimer’s disease usually starts out slow, but eventually results into severe brain damage. ■ The actual cause of death isn't the disease itself, the actual cause of death is usually is a physical illness such as pneumonia. ■ Treatment can slow the process of the disease in some people, but relieving symptoms can improve function significantly. ■ Researcher: KB

References ■ Emedicinehealth. Genes and Disease: Alzheimer’s Disease [online] [cited 2015 March 18]. Available at URL: ■ Huffpost Healthy Living. AOL livestyle [online] [cited 2015 March 18]. Available at URL: disease-progress-research_n_ html disease-progress-research_n_ html ■ Genetics Home Reference. U.S. National Library Medical Chromosome 14. [online] [cited March 18]. Available at URL: