2016-3-181 2010.05.22 刘媛媛. 2016-3-182 3 University of Toronto Professor NSERC/Merck-Frosst Industrial Research Chair AstraZeneca Professor of Organic.

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Presentation transcript:

刘媛媛

3 University of Toronto Professor NSERC/Merck-Frosst Industrial Research Chair AstraZeneca Professor of Organic Chemistry Department of Chemistry Davenport Chemical Laboratories 80 St. George St. University of Toronto Toronto, Ontario M5S 3H6

Personal Place and Date of BirthHamilton, Ontario, CanadaJuly 9, 1959 Education Harvard UniversityNSERC PDF with D. A. Evans University of Wisconsin-MadisonPh.D. with B. M. Trost1985 University of GuelphB.Sc. - Distinction1981 Academic Positions NSERC/Merck Frosst Industrial Research ChairNSERC/Merck Frosst present AstraZeneca Professor of Organic SynthesisUniversity of Toronto present ProfessorUniversity of Toronto Associate ProfessorUniversity of Toronto Assistant ProfessorUniversity of Toronto

Awards & Honors Senior Scientist Award Alexander von Humboldt Foundation Berlin, Aachen and Gottingen Visiting ProfessorUniversity of Berlin2009 Visiting ProfessorUniversité de Marseilles2008 ICIQ Summer SchoolICIQ Tarragona, Spain2008 Attilio Corbella Summer School ProfessorItalian Chemical Society2007 Arthur C. Cope Scholar AwardAmerican Chemical Society2006 Alfred Bader AwardCanadian Society for Chemistry2006 R. U. Lemieux AwardCanadian Society for Chemistry2004 Solvias PrizeSolvias AG2002 Fellow of the Royal Society of CanadaRoyal Society of Canada2001

The Lautens group is focused on the investigation and development of novel transition-metal-mediated organic transformations. Some projects include catalyst-controlled asymmetric transformations while others focus on controlled tandem or domino processes. Of particular interest are reactions which can efficiently construct frameworks of pharmaceutical compounds or fragments of biologically-active natural products.

8 Palladium-Catalyzed Domino Reactions with C-H Bonds: Synthesis of Substituted Carbocycles and Heterocycles using Strained Alkene Shuttles

Palladium-Catalyzed Domino Reactions with C-H Bonds: Synthesis of Substituted Carbocycles and Heterocycles using Strained Alkene Shuttles

The tandem process displays high versatility: Suzuki, Heck, and Sonogashira couplings, as well as direct arylation can be used orthogonally to carbon-nitrogen bond formation under palladium-catalyzed conditions to create a diverse set of 2- substituted indoles, and a wide range of functionality is tolerated at all positions of the benzenoid ring.