1. Synthesis and Reactions of Methyleneaziridines
Chris Hyland
Department of Chemistry and Biochemistry, California State University, Fullerton
Methyleneaziridines are “spring-loaded” highly strained rings that will be activated with transition metals such as palladium in order to access pharmaceutically important pyrrolidines. Palladium is proposed to relieve ring-strain by inserting into the methyleneaziridine to cause ring-expansion
We have successfully prepared novel tethered methyleneaziridines for cyclization to pyrrolidines
Cyclizations have been carried out and the products are currently being identified
A novel rearrangement of methyleneaziridines with a pendant alcohol group has been uncovered and will be exploited for synthesis of biologically interesting dihydrofurans