1. Using the 5-E Method of Teaching in Science Classes Comprehensive Support Summer Institute Summer 2008 Lisa Pierce, MEd NCDPI Science Instructional Facilitator to increase student engagement and motivation

2. Why DESTINY ’ s Modules Help Students Learn DESTINY, UNC-Chapel Hill’s Traveling Science Learning Program

3. The Five E Model Engagement Exploration Explanation Elaboration Evaluation Trowbridge & Bybee, 1990, adapted by Biological Sciencs Curriculum Study http://science.education.nih.gov/supplements/nih1/diseases/guide/module3.htm

4. Engagement Creates interest Generates curiosity Raises questions Elicits responses that uncover what students know or think about the concept or subject

5. Bell-ringer What does biotechnology mean to you?

6. What is Biotechnology? The branch of technology concerned with modern forms of industrial production utilizing living organisms, especially microorganisms and their biological processes. The application of organisms or their products for human use

7. Design a Marketing Plan You are employed by a marketing/public relations company and your customer is a multi-national biotechnology company. Your firm is asked to develop a marketing campaign for one of its new products.

8. Exploration Encourages students to work together without direct instruction from the teacher Observes and listens to students as they interact Asks probing questions to redirect students’ investigations when necessary Provides time for students to puzzle through problems Acts as a consultant for students Creates a “need to know” setting

9. How can you get the bacterial plasmid to produce insulin?

10. Explanation Encourages students to explain concepts and definitions in their own words Asks for justification (evidence) and clarification from students Formally provides definitions, explanations, and new labels when needed Uses students’ previous experiences as the basis for explaining concepts Assesses students’ growing understanding

11. Explain in your own words

12. Bacterial Transformation

13. 3 D Model - Steps in Making Recombinant DNA

14. Elaboration Expects students to use formal labels, definitions, and explanations provided previously Encourages students to apply or extend concepts and skills in new situations Reminds students of alternative explanations Refers students to existing data and asks, “What do you already know?” or “Why do you think…”

15. BOARD MEETING AGENDA Items for discussion at today’s meeting: Preparing for Acme Corporation acquisition Acme Corporation is considering purchasing our company for an enormous sum of money. But before they will vote, the shareholders of Acme Corporation have some questions about genetic modification that require clarification. We will consider each question as an agenda item.

16. Evaluation Observes students as they apply new concepts and skills Assesses students’ knowledge and/or skills Looks for evidence that students have changed their thinking or behaviors Allows students to assess their own learning and group process skills Asks open-ended questions, such as “Why do you think?”, “What evidence do you have?”, What do you know about…?”, “How would you explain…?”

17. Transformation Process 1.A Plasmid is isolated from a bacterial cell 2.The plasmid is cut with a restriction enzyme 3.The gene for making insulin is isolated from a human cell using a restriction enzyme 4.The gene for making insulin is inserted into the plasmid 5.The plasmid is inserted into a bacterial cell 6.The bacterial cell clones itself, producing multiple copies of the recombinant plasmid. 7.The bacteria produce insulin.

18. LET’S DEBRIEF… More information about DESTINY

20. For more information about the DESTINY program, contact destiny@unc.edu http://moreheadplanetarium.org/go/destiny/

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22. For more information about the wet lab materials, go to the Bio-Rad web site. http://explorer.bio-rad.com http://explorer.bio-rad.com This BioBusiness module uses: Bio-Rad’s pGLOTM Bacterial Transformation Kit Catalog # 166-0003EDU 1-800-4BIORAD (1-800-424-6723 )

23. Contact information: Lisa E. Pierce, MEd HS Science Instructional Facilitator Comprehensive Support Innovation and School Transformation NC Department of Public Instruction LPierce@dpi.state.nc.us 919-219-5428