Presentation is loading. Please wait.

Presentation is loading. Please wait.

Fruit and Vegetable and Breast Cancer Publication Smith-Warner, S.A., et al. Intake of fruits and vegetables and risk of breast cancer: A pooled analysis.

Similar presentations


Presentation on theme: "Fruit and Vegetable and Breast Cancer Publication Smith-Warner, S.A., et al. Intake of fruits and vegetables and risk of breast cancer: A pooled analysis."— Presentation transcript:

1 Fruit and Vegetable and Breast Cancer Publication Smith-Warner, S.A., et al. Intake of fruits and vegetables and risk of breast cancer: A pooled analysis of cohort studies. JAMA. 2001 285: 769- 776.

2 Sweden Mammography Cohort Nurses’ Health Study Netherlands Cohort Study New York State Cohort Iowa Women’s Health Study Canadian National Breast Screening Study Adventist Health Study New York University Women’s Health Study Studies in the Pooled Analysis of Fruits and Vegetables and Breast Cancer Total = 351,825 # cases = 7,377

3 Cohort Studies in the Pooled Analysis of Fruits and Vegetables and Breast Cancer Study Baseline # of Cohort Cases Adventist Health 15,172160 Canadian National 56,837419 Iowa Women’s 34,406 1130 Netherlands Cohort 62,412937 New York State 18,475367 New York University 14,006385 Nurses’ Health (a) 89,046 1023 Nurses’ Health (b) 68,817 1638 Sweden Mammography 61,471 1318 Smith-Warner, et al. 2001

4 Median Intakes (g/d) Among Control Participants Study Total Total Fruits Vegetables Adventist Health 355 162 Canadian National 327 226 Iowa Women’s 342 196 Netherlands Cohort 206 164 New York State 297 189 New York University 293 198 Nurses’ Health (a) 284 155 Nurses’ Health (b) 336 262 Sweden Mammography 164 77 Smith-Warner, et al. 2001

5 Pooled Multivariate Relative Risks for Breast Cancer and Fruits and Vegetables 1 1.00 (ref) 1.00 (ref) 20.94 (0.87-1.01) 0.99 (0.90-1.08) 3 0.92 (0.86-0.99) 0.97 (0.90-1.05) 40.93 (0.86-1.00) 0.96 (0.89-1.04) p for trend0.080.54 p for hetero.0.940.73 Quartile Total Fruits Total Vegetables RR (95% CI) RR (95% CI) Smith-Warner, et al. 2001

6 Pooled Multivariate Relative Risks of Breast Cancer and Total Fruits and Vegetables Smith-Warner, et al. 2001 Relative Risk Quartile of Intake 1 2 3 4

7 Study-Specific Relative Risks of Breast Cancer and Total Fruits Relative Risk.811.25 Combined Sweden Nurses' (b) Nurses' (a) NY University NY State Netherlands Iowa Canada Adventist Smith-Warner, et al. 2001

8 Study-Specific Relative Risks of Breast Cancer and Total Vegetables Relative Risk.711.5 Combined Sweden Nurses' (b) Nurses' (a) NY University NY State Netherlands Iowa Canada Adventist Smith-Warner, et al. 2001

9 Pooled Multivariate Relative Risks of Breast Cancer and Botanically Defined Groups Group Examples RR (95% CI) Cruciferae Broccoli, cabbage 0.96 (0.87-1.06) Leguminosae Beans, peas 0.97 (0.87-1.08) Rosaceae Apples, peaches 0.97 (0.94-1.00) Rutaceae Grapefruits, oranges 0.99 (0.97-1.01) Solanacea Potatoes, tomatoes 1.02 (0.99-1.05) Increment=100 g/d Smith-Warner, et al. 2001

10 Pooled Multivariate Relative Risks of Breast Cancer and Specific Foods Food RR (95% CI) Apples, pears 0.97 (0.93-1.01) Bananas 1.00 (0.93-1.08) Oranges, tangerines 0.98 (0.92-1.05) Broccoli 0.86 (0.72-1.02) Carrots 0.95 (0.81-1.12) Lettuce 0.93 (0.84-1.02) Increment = 100g/d Smith-Warner, et al. 2001

11 Pooled Multivariate Relative Risks of Breast Cancer and F & V by Menopausal Status Multi RR (95% CI) p-for - (increment=100 g/d) interaction Total fruits Premeno. 0.98 (0.94-1.02) Postmeno. 0.99 (0.98-1.01)0.80 Total vegetables Premeno. 0.99 (0.93-1.06) Postmeno. 1.00 (0.97-1.02)0.54 Total fruits and vegetables Premeno. 0.99 (0.96-1.02) Postmeno. 1.00 (0.98-1.01)0.57 Smith-Warner, et al. 2001


Download ppt "Fruit and Vegetable and Breast Cancer Publication Smith-Warner, S.A., et al. Intake of fruits and vegetables and risk of breast cancer: A pooled analysis."

Similar presentations


Ads by Google