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Carotenoids and Lung Cancer Publication Männistö, S., et al. Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies.

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Presentation on theme: "Carotenoids and Lung Cancer Publication Männistö, S., et al. Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies."— Presentation transcript:

1 Carotenoids and Lung Cancer Publication Männistö, S., et al. Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies. Cancer Epidemiology, Biomarkers and Prevention, 2004; 13:

2 Nurses’ Health Study Netherlands Cohort Study New York State Cohort Iowa Women’s Health Study Canadian National Breast Screening Study Alpha-Tocopherol Beta-Carotene Cancer Prevention Study Health Professionals Follow-up Study Cohort Studies Included in the Pooled Analysis of Carotenoids and Lung Cancer Total = 399,765 # cases = 3,155 Männistö, et al. 2004

3 Study Baseline # of Cohort Cases ATBC 6, Canadian National 56, Health Professionals44, Iowa Women’s 33, Netherlands Cohort (W) 62, Netherlands Cohort (M) 58, New York State (W) 21, New York State (M) 27, Nurses’ Health (a) 88, Nurses’ Health (b) 68, Cohort Studies in the Pooled Analysis of Carotenoids and Lung Cancer Männistö, et al. 2004

4 Mean Carotenoid Intakes (mcg/d) Study Alpha- Beta- Beta- carotene carotene cryptoxanthin ATBC Canadian National Health Professionals Iowa Women’s Netherlands Cohort (W) Netherlands Cohort (M) New York State (W) New York State (M) Nurses’ Health (a) Nurses’ Health (b) Männistö, et al. 2004

5 Mean Carotenoid Intakes (mcg/d) (cont’d) Study Lutein/Lycopene Zeaxanthin ATBC Canadian National Health Professionals Iowa Women’s Netherlands Cohort (W) Netherlands Cohort (M) New York State (W) New York State (M) Nurses’ Health (a) Nurses’ Health (b) Männistö, et al. 2004

6 Alpha- and Beta-Carotene and Lung Cancer: Pooled Multivariate Relative Risks by Quintile Quintile Alpha- Beta- carotene carotene ( ) 0.97 ( ) ( ) 1.00 ( ) ( ) 0.94 ( ) ( ) 0.98 ( ) p for trend p for het. for Q Männistö, et al. 2004

7 Lutein and Lycopene and Lung Cancer: Pooled Multivariate Relative Risks by Quintile Quintile Lutein/ Lycopene Zeaxanthin ( ) 0.86 ( ) ( ) 0.85 ( ) ( ) 0.88 ( ) ( ) 0.91 ( ) p for trend p for het. for Q Männistö, et al. 2004

8 Beta-Cryptoxanthin and Lung Cancer: Pooled Relative Risks by Quintile Quintile Age-adjusted Multivariate ( ) 0.90 ( ) ( ) 0.83 ( ) ( )0.86 ( ) ( ) 0.76 ( ) p for trend <0.001<0.001 p for het. for Q Männistö, et al. 2004

9 Pooled Multivariate Relative Risks for Lung Cancer by Categories of Beta-Cryptoxanthin Relative Risk Männistö, et al. 2004

10 Study-Specific Multivariate RRs (Quintile 5 vs. 1) for Beta-Cryptoxanthin and Lung Cancer Männistö, et al. 2004

11 Beta-Cryptoxanthin and Lung Cancer: Pooled Multivariate Relative Risks by Smoking Status Quartile Never Past Current n=259 n=981 n= ( ) ( ) ( ) p for trend <0.001 p for het. due to smoking status for Q4 = 0.30 Männistö, et al. 2004

12 Beta-Cryptoxanthin and Lung Cancer: Pooled Multivariate Relative Risks by Cell Type Quartile Adeno. Small Squamous n=956 n=538 n= ( ) ( ) ( ) p for trend <0.001 p for common effects by cell type for Q4 = 0.24 Männistö, et al. 2004

13 Beta-Carotene and Lung Cancer: Pooled Multivariate Relative Risks by Smoking Status Quartile Never Past Current n=259 n=981 n= ( ) ( ) ( ) p for trend p for het. due to smoking status for Q4 = 0.83 Männistö, et al. 2004

14 Beta-Carotene and Lung Cancer: Pooled Multivariate Relative Risks by Cell Type Quartile Adeno. Small Squamous n=956 n=538 n= ( ) ( ) ( ) p for trend p for common effects by cell type for Q4 = 0.66 Männistö, et al. 2004


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