1. MCW-2 5-chloro-2-(3,4,4-trifluoro-but-3-ene-1-sulfonyl)- thiazole A New Proprietary Nematocide from Makhteshim Chemical Works

2. 1 Chemistry

3. 2 Proprietary Molecule Preliminary data available on: Toxicology Mode of Action Spectrum of Activity Global development project begun in 2008 Joint OECD Review – North America, South America, Western Europe, Japan Global registrations expected 2013-2014

4. 3 Efficacy and Operational Use Formulations: –1.5% Granular –Emulsifiable Concentrate (EC 48%) –Slow release formulations (25 CS) under development for drench / drip application. Crops: – Fruiting Vegetables – Cucurbits –Potatoes, Tobacco, Bananas Nematode Targets: Meloidogyne spp., Rhadopholus spp., Pratylencus spp.

5. 4 Activity of MCW2 against Meloidogyne javanica Chart 1. shoot fresh weight tomato plants grown in soil not inoculated (A) and inoculated with Meloidogyne javonica (B). Diagram C shows the severity of infection of tomato roots on a scale of 0-5. A B C No M.javanica Inoculated M.javanica Severity of Infection

6. 5 Acts as a true nematocide - kills nematodes thru contact with the product. This is a significant difference in comparison with all other non-fumigant nematocides (P-ester, carbamates) which only inactivate nematodes as long as the active ingredient is present. High level of efficacy against root-knot nematodes (Meloidogyne spp.) –Good residual activity –Clear dose response –Less variable than standards –New mode of action Good crop safety after soil incorporation Root systemic No insecticidal effects MCW2 in Crop Protection

7. 6 Nematocidal activity of MCW2 against Meloidogyne javanica Cahrt 2. % of paralyzed larva of Meloidogyne javonica after exposure to nematocides for 24h(A), 48h(B). And 24h after wash by water (C). 24 Hr Exposure 48 Hr Exposure 24 Hr After Wash

8. Suggested GAP 480 EC: Pre application 1.5 – 2 kg. a.i per ha. Post application (depend on residues results and efficacy trials) 1 – 1.5 kg. a.i. per ha. Crops – Vegetables, Potatoes, Flowers, Bananas and others. GR 1.5% Pre application 2 – 2.5 kg. a.i. per ha. Mainly for the Japanese market. Crops - Vegetables, Potatoes, Flowers Plan to finalize in 2008.

9. 8 Acute Toxicology Toxicology: Acute oral, ratLD50>500mg/kg Dermal, ratLD50 >4000mg/kg Inhalation, ratLC50>5058mg/m3 air Subchronic feeding, ratNOAEL 4.3mg/kg MutagenicityNegative in pilot tests Developmental ToxNo prohibitive results in pilot studies (rats, rabbits) Eye irritation (rabbit)No irritant effect to the eye Skin irritation (rabbit)No irritant effect to the skin Skin sensitization (MT in guinea pigs) + Sensitizer

10. 9 Efate & Ecotox Ecotoxicology: No prohibitive findings regarding beneficial and non-target organisms (no insecticidal activity). Environmental Fate: Moderate soil degradation and soil absorption. Low leaching potential expected.

11. Nematocide Products Comparison Trade NameMCW2NemathorinNamacurTemikVidete Active ingredient fosthiazatefenamiphosaldicarboxamyl Chemical class fluoroalkenyleOrganophospha te carbamate US registration ISK BIOSCIENCES CORPORATION BAYER CORP BAYER CROPSCIENCE LP (Cancelled in Europe on 7/21/05) E. I. Du Pont Acute oral tox (LD 50 ) Between 500 and 1,000 mg/kg 73 mg/kg (M) 51-64 mg/kg (F)(Category II) 1 2.7 mg/kg (M) 3.0 mg/kg (F) (Category I) 2 0.8 mg/kg 3 (Category I) 5.4 mg/kg 5 (Category I) Acute dermal (LD 50 ) > 4,000 mg/kg2396 mg/kg( M) 861 mg/kg( F) 1 (Category II) 225 mg/kg (M) 178.8 mg/kg (F) 2 (Category I) 20 mg/kg/day, water 5 mg/kg, propylene glycol 3 (Category I) 2960 mg/kg 5 (Category III) Acute Inhalation (LC 50 ) LC50>5,058 mg/L 0.83 mg/L(M) 0.56 mg/L(F) 1 (Category III) LC50 = >0.1 mg/L 2 (Category II) LC50 < 0.007 mg/L 3 (Category I) 0.12-0.17 mg/L 5 (Category II) IrritationNon irritant eye and skin Mildly eye irritating; non- skin irritating 1 Mildly eye irritating; non- skin irritating 2 No irritation at lethal dose 3 Mildly eye irritating; non-skin irritating 4 Dermal sensitization PositivePositive 1 Negative 2 Negative 3 Negative 4 OthersNew ai ; no REDIREDIRED is scheduled 3/2007 IRED 2000 1 EPA Fosthiazate RED Fact Sheet (2004) 2 EPA Fenamiphos IRED (2002) 3 EPA aldicarb HED and EFED Chapter (2006) 4 EPA oxmyl IRED (2000) 5 Extoxnet oxmyl

12. Ecotoxicity Trade Name MCW2 * Nemathorin 1 Namacur 2 Temik 3 Videte 4 Active ingredientfosthiazatefenamiphosaldicarboxamyl Chemical classfluoroalkenyleOrganophospha te carbamate BirdsNon toxicHighly toxic Very highly toxic Acutely toxic Freshwater fishLowNon toxicHighly toxic (also its degradates) Very highly to moderately toxic Toxic Freshwater Invertebrates ModerateAcutely highly toxic Highly toxic(also its degradates) Highly toxic Honey beeNot toxicHighly toxic (acute basis) Highly toxic Moderately to high toxic Wild mammalsn.a. Highly toxicVery highly toxic Acutely toxic EarthwormsNon toxicHighly toxic Bioaccumulation 10 lowmoderatelylow * Bayer BYI 1921 Early Development Nematocide Nematocide Products Comparison, cont.

13. 12 Major Global Markets and Current Major Products that MCW2 could replace (Preliminary information) USA - ALDICARB, CHLOROPICRIN, DICHLOROPROPENE, ETHOPROPHOS, FENAMIPHOS, OXAMYL, METAM SODIUM, CADUSAFOS, FOSTHIAZATE, METHYL BROMIDE Canada - The Canadian Pest Management Regulatory Agency (PMRA) has extended the use of American Vanguard's granular organophosphate insecticides, Thimet 15G (phorate) and Counter 15G (terbufos), until 2012. The extended phase-outs are necessary because of the lack of alternative products to control wireworms (Agriotes spp) in potatoes and sugar beet, respectively, the PMRA points out. Japan - CADUSAFOS, Oxamyl, Carbosulfan, Pyraclofos enfuracarb, Fosthiazate, Dazomet Brazil - ALDICARB, CADUSAFOS, CARBOFURAN, DAZOMET, TERBUFOS Europe – 1,3- DICHLOROPROPENE, ALDICARB, METAM SODIUM, CADUSAFOS, FENAMIPHOS, FOSTHIAZATE, METHYL BROMIDE Africa – As above

14. 13 Regulatory Plan and actions Regulatory study program underway OECD review planned and coordinated Discussions held with regulatory bodies: – EPA, Ireland, Japan, Canada, Brazil Will present to the OECD Joint Review Committee in Paris (Nov 6th) First Global registrations anticipated in 2013-2014