1. GO-Slim term : ProcessCluster frequency total proteinsCluster frequencyGenes annotated to the term regulation of biological process 321 out of 1261 genes, 25.5%20 out of 55 genes, 36.4% 0.02146784ACO1, ACT1, AHP1, CDC12, CDC48, ERG1, FBA1, HSP60, HSP70, HSP90, LPD1, MET6, PFY1, PIN3, SSB1, SSC1, TIM9, TPI1, TRX1, orf19.5281 transport 251 out of 1261 genes, 19.9%16 out of 55 genes, 29.1% 0.03031356ACT1, ATP5, CDC48, FBA1, HSP60, HSP70, NTF2, PFY1, PMM1, RPS3, SSA2, SSB1, SSC1, TEF1, TIM9, TRX1 response to stress 241 out of 1261 genes, 19.1%16 out of 55 genes, 29.1% 0.02291991ACT1, AHP1, CDC48, ERG1, HSP60, HSP70, HSP90, MET6, NOC2, PHR1, RHR2, SSA2, SSB1, TPI1, TRX1, orf19.5281 organelle organization 286 out of 1261 genes, 22.7%15 out of 55 genes, 27.3% 0.08839355ACO1, ACT1, CDC12, CDC48, HSP60, HSP90, PFY1, PMM1, RIM1, SSA2, SSC1, TIM9, TPM2, TRX1, orf19.5281 response to chemical 195 out of 1261 genes, 15.5%12 out of 55 genes, 21.8% 0.05928833ACT1, AHP1, CDC48, ERG1, HSP70, HSP90, NOC2, PHR1, RPL17B, SSA2, TRX1, orf19.5281 filamentous growth 140 out of 1261 genes, 11.1%11 out of 55 genes, 20% 0.02000988ACT1, CDC12, ERG1, HSP90, LPD1, NOC2, PHR1, SSB1, TPI1, TPM2, TRX1 generation of precursor metabolites and energy 66 out of 1261 genes, 5.2%10 out of 55 genes, 18.2% 0.0002798767ACO1, COX5, FBA1, FUM11, FUM12, GPM1, MAM33, PDC11, QCR2, TPI1 interspecies interaction between organisms 40 out of 1261 genes, 3.2%10 out of 55 genes, 18.2% 3.016133e-06ACO1, FBA1, GPM1, HSP70, MET6, PHR1, SSA2, SSB1, TEF1, TPI1 carbohydrate metabolic process 96 out of 1261 genes, 7.6%9 out of 55 genes, 16.4% 0.01304901FBA1, GPM1, PDC11, PHR1, PMM1, RHR2, TAL1, TKL1, TPI1 cell cycle 127 out of 1261 genes, 10.1%7 out of 55 genes, 12.7% 0.132987ACT1, CDC12, CDC48, LPD1, PFY1, TPM2, orf19.5281 translation 135 out of 1261 genes, 10.7%7 out of 55 genes, 12.7% 0.1456061HCR1, RPL17B, RPP2B, RPS3, SSB1, TEF1, orf19.3690.2 cellular respiration 39 out of 1261 genes, 3.1%6 out of 55 genes, 10.9% 0.004525711ACO1, COX5, FUM11, FUM12, MAM33, QCR2 protein folding 50 out of 1261 genes, 4%6 out of 55 genes, 10.9% 0.01402609HSP60, HSP70, HSP90, SSA2, SSB1, SSC1 cytoskeleton organization 62 out of 1261 genes, 4.9%5 out of 55 genes, 9.1% 0.07984212ACT1, CDC12, CDC48, PFY1, TPM2 response to drug 88 out of 1261 genes, 7%5 out of 55 genes, 9.1% 0.1577981ERG1, HSP90, NOC2, PHR1, RPL17B cytokinesis 33 out of 1261 genes, 2.6%4 out of 55 genes, 7.3% 0.03949144ACT1, CDC12, PFY1, TPM2 biological process unknown 136 out of 1261 genes, 10.8%4 out of 55 genes, 7.3% 0.13688AHP2, RCT1, orf19.4609, orf19.5676 hyphal growth 39 out of 1261 genes, 3.1%3 out of 55 genes, 5.5% 0.1539067ACT1, CDC12, PHR1 conjugation 25 out of 1261 genes, 2%3 out of 55 genes, 5.5% 0.07093105PFY1, TPM2, orf19.5281 ribosome biogenesis 104 out of 1261 genes, 8.2%3 out of 55 genes, 5.5% 0.1678977HCR1, RPS3, SSB1 cellular homeostasis 47 out of 1261 genes, 3.7%3 out of 55 genes, 5.5% 0.1926411AHP1, LPD1, TRX1 vesicle-mediated transport 77 out of 1261 genes, 6.1%3 out of 55 genes, 5.5% 0.2299261ACT1, PMM1, TRX1 cell adhesion 17 out of 1261 genes, 1.3%2 out of 55 genes, 3.6% 0.1328706PHR1, RHR2 cell wall organization 42 out of 1261 genes, 3.3%2 out of 55 genes, 3.6% 0.2801906ACT1, PHR1 cellular protein modification process 86 out of 1261 genes, 6.8%2 out of 55 genes, 3.6% 0.1622587ACT1, TRX1 biofilm formation 33 out of 1261 genes, 2.6%2 out of 55 genes, 3.6% 0.255921PHR1, RHR2 RNA metabolic process 164 out of 1261 genes, 13.0%2 out of 55 genes, 3.6% 0.01428547HCR1, SSB1 signal transduction 42 out of 1261 genes, 3.3%2 out of 55 genes, 3.6% 0.2801906HSP90, orf19.5281 DNA metabolic process 72 out of 1261 genes, 5.7%2 out of 55 genes, 3.6% 0.2156223ACT1, HSP90 pathogenesis 64 out of 1261 genes, 5.1%2 out of 55 genes, 3.6% 0.2445914HSP90, PHR1 nucleus organization 20 out of 1261 genes, 1.6%1 out of 55 genes, 1.8% 0.3771988PMM1 pseudohyphal growth 12 out of 1261 genes, 1%1 out of 55 genes, 1.8% 0.322641TPM2 protein catabolic process 71 out of 1261 genes, 5.6%1 out of 55 genes, 1.8% 0.131991CDC48 lipid metabolic process 55 out of 1261 genes, 4.4%1 out of 55 genes, 1.8% 0.213801ERG1 can not be mapped to a GO slim term149 out of 1261 genes, 11.8%7 out of 55 genes, 12.7% 0.1596781APE2, GRP2, LSC1, RNR21, orf19.2244, orf19.3175, orf19.5517

2. GO-Slim term: Component Cluster frequency total proteins Cluster frequencyGenes annotated to the term cytoplasm 1006 out of 1261 genes, 79.8% 51 out of 55 genes, 92.7% 0.005023286 ACO1, ACT1, AHP1, APE2, ATP5, CDC12, CDC48, COX5, ERG1, FBA1, FUM11, FUM12, GPM1, GRP2, HCR1, HSP60, HSP70, HSP90, LPD1, LSC1, MAM33, MET6, NOC2, NTF2, PDC11, PFY1, PIN3, PMM1, QCR2, RCT1, RHR2, RIM1, RNR21, RPL17B, RPP2B, RPS3, SSA2, SSB1, SSC1, TAL1, TEF1, TIM9, TKL1, TPI1, TPM2, TRX1, orf19.3175, orf19.3690.2, orf19.4609, orf19.5281, orf19.5676 mitochondrion 347 out of 1261 genes, 27.5% 24 out of 55 genes, 43.6% 0.003596512 ACO1, APE2, ATP5, CDC48, COX5, FBA1, FUM11, GPM1, HSP60, HSP90, LPD1, LSC1, MAM33, NOC2, QCR2, RCT1, RIM1, SSA2, SSC1, TEF1, TIM9, TPI1, TRX1, orf19.3175 nucleus 556 out of 1261 genes, 44.1%23 out of 55 genes, 41.8% 0.104445 ACT1, CDC48, FBA1, GPM1, GRP2, HSP70, MET6, NOC2, NTF2, PDC11, PFY1, PIN3, PMM1, RHR2, RNR21, TAL1, TEF1, TIM9, TKL1, TPI1, TRX1, orf19.3690.2, orf19.5676 membrane 343 out of 1261 genes, 27.2% 22 out of 55 genes, 40% 0.01237556 ACT1, AHP1, ATP5, CDC48, COX5, ERG1, FBA1, HSP70, HSP90, MET6, PDC11, PFY1, PHR1, QCR2, RCT1, SSA2, SSB1, SSC1, TIM9, TKL1, TPI1, orf19.5281 plasma membrane 170 out of 1261 genes, 13.5% 17 out of 55 genes, 30.9% 0.0003360052 AHP1, CDC48, COX5, ERG1, FBA1, HSP70, HSP90, MET6, PDC11, PFY1, PHR1, QCR2, SSA2, SSB1, SSC1, TKL1, TPI1 cell wall 65 out of 1261 genes, 5.2% 15 out of 55 genes, 27.3% 2.047743e-08 AHP1, APE2, FBA1, GPM1, HSP70, HSP90, MET6, PDC11, PHR1, SSA2, SSB1, SSC1, TEF1, TKL1, TPI1 mitochondrial envelope 113 out of 1261 genes, 9% 8 out of 55 genes, 14.5% 0.06058599 ATP5, CDC48, COX5, GPM1, QCR2, SSC1, TIM9, TRX1 extracellular region 62 out of 1261 genes, 4.9% 8 out of 55 genes, 14.5% 0.003217363 APE2, LPD1, MET6, PHR1, RPL17B, TAL1, TEF1, orf19.4609 ribosome 113 out of 1261 genes, 9% 6 out of 55 genes, 10.9% 0.1540328 CDC48, RCT1, RPL17B, RPP2B, RPS3, orf19.3690.2 cell cortex 48 out of 1261 genes, 3.8% 5 out of 55 genes, 9.1% 0.03821097 ACT1, CDC12, PFY1, PIN3, TPM2 cytoskeleton 56 out of 1261 genes, 4.4%4 out of 55 genes, 7.3% 0.1324179ACT1, CDC12, PIN3, TPM2 site of polarized growth 66 out of 1261 genes, 5.2%4 out of 55 genes, 7.3% 0.1683337ACT1, CDC12, CDC48, TPM2 cellular bud 53 out of 1261 genes, 4.2%4 out of 55 genes, 7.3% 0.1201694ACT1, CDC12, PHR1, TPM2 endoplasmic reticulum 80 out of 1261 genes, 6.3%3 out of 55 genes, 5.5% 0.2256669CDC48, ERG1, orf19.5281 cellular component unknown 6 out of 1261 genes, 0.5% 3 out of 55 genes, 5.5% 0.001386456 AHP2, orf19.2244, orf19.5517 vacuole 35 out of 1261 genes, 2.8%3 out of 55 genes, 5.5% 0.131115ERG1, SSA2, TRX1 endomembrane system 89 out of 1261 genes, 7.1%3 out of 55 genes, 5.5% 0.2076977CDC48, NTF2, orf19.5281 peroxisome 33 out of 1261 genes, 2.6%2 out of 55 genes, 3.6% 0.255921ACT1, APE2 nucleolus 71 out of 1261 genes, 5.6%2 out of 55 genes, 3.6% 0.2194046NOC2, orf19.3690.2 hyphal tip 16 out of 1261 genes, 1.3%2 out of 55 genes, 3.6% 0.1224516ACT1, TPM2

3. GO-Slim term: Function Cluster frequency total proteins Cluster frequencyGenes annotated to the term protein binding 178 out of 1261 genes, 14.1%15 out of 55 genes, 27.3% 0.00413539CDC12, CDC48, FBA1, GPM1, HSP60, HSP70, HSP90, NTF2, PFY1, SSA2, SSB1, SSC1, TEF1, TIM9, orf19.5281 oxidoreductase activity 166 out of 1261 genes, 13.2%12 out of 55 genes, 21.8% 0.02619823AHP1, AHP2, COX5, ERG1, GRP2, LPD1, QCR2, RNR21, TRX1, orf19.2244, orf19.3175, orf19.5517 hydrolase activity 214 out of 1261 genes, 17%12 out of 55 genes, 21.8% 0.08479468APE2, ATP5, CDC12, CDC48, HSP60, HSP90, PHR1, RHR2, SSB1, SSC1, TEF1, orf19.4609 lyase activity 38 out of 1261 genes, 3.0%6 out of 55 genes, 10.9% 0.00398928ACO1, FBA1, FUM11, FUM12, PDC11, RPS3 structural molecule activity 105 out of 1261 genes, 8.3%6 out of 55 genes, 10.9% 0.1388934ACT1, CDC12, RPL17B, RPP2B, RPS3, orf19.3690.2 transferase activity 167 out of 1261 genes, 13.2%6 out of 55 genes, 10.9% 0.150206ACT1, MET6, PHR1, TAL1, TKL1, orf19.5517 molecular function unknown 236 out of 1261 genes, 18.7%5 out of 55 genes, 9.1% 0.02375213MAM33, NOC2, PIN3, RCT1, TPM2 RNA binding 116 out of 1261 genes, 9.2%5 out of 55 genes, 9.1% 0.1880254HCR1, RPS3, TEF1, orf19.3690.2, orf19.5281 isomerase activity 27 out of 1261 genes, 2.1%4 out of 55 genes, 7.3% 0.02183008GPM1, PMM1, TPI1, TRX1 transporter activity 79 out of 1261 genes, 6.3%4 out of 55 genes, 7.3% 0.1984733ATP5, COX5, QCR2, TIM9 DNA binding 76 out of 1261 genes, 6.0%3 out of 55 genes, 5.5% 0.2311094ACO1, HSP60, RIM1 lipid binding 41 out of 1261 genes, 3.3%2 out of 55 genes, 3.6% 0.2789673CDC12, PFY1 ligase activity 61 out of 1261 genes, 4.8%1 out of 55 genes, 1.8% 0.1800337LSC1 peptidase activity 40 out of 1261 genes, 3.2%1 out of 55 genes, 1.8% 0.3076956APE2 phosphatase activity 17 out of 1261 genes, 1.3%1 out of 55 genes, 1.8% 0.366317RHR2 enzyme regulator activity 41 out of 1261 genes, 3.3%1 out of 55 genes, 1.8% 0.3014397SSC1 can not be mapped to a GO slim term53 out of 1261 genes, 4.2%1 out of 55 genes, 1.8% 0.2257677orf19.5676