Presentation on theme: "Reishi and Immunity: A Scientific Overview"— Presentation transcript:
1Reishi and Immunity: A Scientific Overview Presented by Michael N. Chang, Ph.D. Chief Scientific Advisor, Nu Skin Enterprises, Inc.This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.
2The Human Immune System ...…is a complicated network of cells, antibodies and proteins that serves following three main functions:1. Removes waste and harmful material, to ensure the normal function of the body.2. Defends against pathogens - bacteria, fungi and virus.3. Kills and removes dead cells that have been altered as a natural process of the cell rejuvenation function.… is delicately balanced by a very sophisticated feedback regulation and control system
3Immune Cells Recognize and Destroy: Invading Organisms and Damaged Cells Chemical message alerts immune system that an invader is presentImmune cell “swallows” foreign invader
4Cell Surface Antigen How does it work? Pathogens, such as bacteria, fungus, virus, have carbohydrates protruding outside of its surface.Cells that have been altered during the normal cell rejuvenation process also have carbohydrate antigens protruding.
5Reishi MushroomReishi (Ganoderma lucidum) mushroom is a fungus occurring as a shelf-like form growing on trees and stumps in densely wooded mountainous areas with high moisture and low light.The spores of Reishi have tough outer shells that make it difficult to obtain the nutrients inside. The rarity of Reishi is partly attributed to the difficulty of germination.
6Reishi Growing Process Zoom in of Reishi body11. Reishi body2. Basidiomycete producessporidium3. Mycelium32Growth of Basidiomycete
7Types of ReishiThere are 62 types of Reishi, of which six are most common:RED BLACKBLUE WHITEYELLOW PURPLERED Reishi is preferred because it can produce the highest quality extract and has been subject to the most scientific evaluation
8Cultivation of ReishiIn 1971, Yukio Naoi, a researcher of the Kyoto University in Japan, successfully developed the artificial cultivation of Reishi, which resulted in reproducible and consistent production of Reishi.
10Reishi Spores These highly active substances are the essence of Reishi They are the reproductive cells that are released at maturityHowever, Reishi spores are protected by an extremely hard shell which prevent us from optimally absorbing the actives
11Traditional UseReishi, also known as Lingzhi, is one of the most valued herbal products in Traditional Chinese Medicine (TCM)Reishi’s earliest herbal remedies were recorded between 206 B.C. - 8 A.D.In Taiwan, families often give Reishi to their aging grandparents
12Clinical Research Approach for Reishi The polysaccharides of Reishi can support our immune system.It is generally recognized that certain polysaccharides cannot be absorbed by the human body.When our intestine senses the presence of certain polysaccharides, receptors within our body will create a series of signals which then stimulate the body to carry out biological actions that support the immune system.
13Research Findings: Reishi Mushroom & Extracts Cell supportImmune system supportLiver supportNervous system supportCardiovascular protection and blood sugar support
14Pre-Clinical StudiesAnimal and in vitro studies have shown that Reishi extracts:Supports activity of lymphocytes and natural killer (NK) cellsSupports activity of cytokines and macrophagesSupports healthy, normal histamine release from mast cellsWang SY, et al. 1997;70(6): Lu Z, Lin ZB International Symposium on Ganoderma Research, October 24-26, 1994, Beijing Medical University, Beijing , China, Program and Abstracts, p. 82.
15Clinical StudiesIn clinical studies, Reishi extracts have been shown to:Supports healthy levels of immune cells and antibodiesImprove vigor and appetiteKupin, V. (1992). The 4th International Symposium on Ganoderma lucidum, Hyatt Regency hotel, June 10, 1992, Seoul, Korea, Program and Abstracts, pp Yang QY, Wang, M. M. (1996) Taipei International Ganoderma Research Conference, Taipei International Convention Center (TICC), August 15-15, 1996, Abstracts, Special Lecture.
16Application for Reishi Reishi supports the immune system’s ability to recognize unwanted organisms and cells that may have been damaged as a normal effect of the cell rejuvenation function.Reishi supports optimal healthsupports the body’s formation of antibodiessupports the body’s ability to proliferate immune cellsmodulates the function of Natural Killer (NK) cells
17Optimal Immune System Support Presented by Jia-Shi Zhu, M.D., Ph.D. Director of Clinical and Pharmacology Affairs, Pharmanex, LLC
18Scientifically Proven Health Benefits Supports healthy immune system functions*Stimulates proliferation of defensive immune cells in your body, including NK cells** These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
19Use of the best Reishi species: RED Reishi or Ganoderma lucidumUse of the best Reishi cultivation method:solid tree trunk, organic cultivation for daysFree of pesticides, free of heavy metals, and no unwanted microbial contamination
20Use of Pharmanex’ proprietary manufacturing process to extract active components from Reishi
23ReishiMax Pre-Clinical Studies A recent comparative study demonstrated supportive immune functions by ReishiMax:Supports the formation of antibodies*Supports proliferation of immune cells*Supports NK cell functions** These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
24ReishiMax supports humoral immune functions* Placebo0.5851.170ReishiMax GLP2.925(g/kg)OtherReishi+25%+27%+15%p=0.01p<0.01 by ANOVA0.00.20.40.60.81.01.21.41.6Serum IgG (mg/ml)By Medical Institute at National Taiwan University* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
25ReishiMax supports cell-mediated immune functions* Placebo0.5851.170ReishiMax GLP2.925(g/kg)OtherReishi10002000300040005000Interleukin-2 (pg/ml)p<0.001 by ANOVA+405%+822%+799%p=0.12By Medical Institute at National Taiwan University* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
26Higher Amount of Actives min1020304050mAU100200Other Reishi productGAGanoderol BGanoderol acid DM-stdReishiMax
27Recent Publications ReishiMax GLp contains unique polysaccharides that are responsiblefor immune supporting activitiesConducted by Pharmanex SAB member Chi-Huey Wong at Academia Sinica in TaiwanPublished: Wang YY, Wong CH, et al. Bioorganic & Medicinal Chemistry 2002;10:Three new active compounds (lanostanoids) identified in ReishiConducted by Pharmanex Scientists J. Chang, M. Chang, and others.Published: Ma J, Ye Q, et al. Journal of Natural Products 2002;65(1):72-75.
28Higher Solubility ReishiMax Reishi A Reishi B 90% 71% 80% 70% 51% 60% 10%20%30%40%50%60%70%80%ReishiMaxReishi AReishi BBy Pharmanex Research Center at Shanghai Medical University
29Competitive Advantage 6S processBest natural Red Reishi speciesOrganic cultivationCracked sporesProprietary manufacturing technologyHighest level of actives on the marketScientifically provenHealth food license granted by Taiwan DOH
30Recommended Usage Take twice daily with meals: 1 capsule each time for health maintenance2 capsules each time for immune modulationSafe and well tolerated at the recommended dosage
31Taken together, ReishiMax and Tegreen provide a comprehensive cellular health maintenance program* * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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